p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3

Stable Identifier
R-HSA-6784791
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Once phosphorylated, STAT3 dissociates from the receptor, dimerizes with other STAT3 molecules, and translocates to the nucleus where it binds with high affinity to STAT-binding elements (SBEs) in the promoters of IL-10-inducible genes (Donnelly et al. 1999).

Literature References
PubMed ID Title Journal Year
10433356 The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes

Donnelly, RP, Dickensheets, H, Finbloom, DS

J. Interferon Cytokine Res. 1999
Participants
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Orthologous Events
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