Degradation of PCSK9:LDLR:Clathrin-coated vesicle

Stable Identifier
R-HSA-6784738
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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LDLR that engage PCSK9 at the cell membrane are internalized via the canonical clathrin-dependent endocytic machinery (Wang et al. 2012). This complex is routed to lysosomes via a pathway that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve the proteasomal or autophagy pathways. The clathrin is required for the internalization of the LDLR-PCSK9 complex that forms on the cell surface.

Literature References
PubMed ID Title Journal Year
22764087 Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Wang, Y, Huang, Y, Hobbs, HH, Cohen, JC

J. Lipid Res. 2012
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