PCSK9:LDLR bind to Clathrin

Stable Identifier
R-HSA-6784735
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, clathrin-coated endocytic vesicle membrane
ReviewStatus
5/5
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PCSK9:LDLR bind to Clathrin
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LDLR that engage PCSK9 at the cell membrane are internalized via the canonical clathrin-dependent endocytic machinery (Wang et al. 2012). This complex is routed to lysosomes via a pathway that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve the proteasomal or autophagy pathways. The clathrin is required for the internalization of the LDLR-PCSK9 complex that forms on the cell surface.
Literature References
PubMed ID Title Journal Year
22764087 Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Huang, Y, Hobbs, HH, Cohen, JC, Wang, Y

J. Lipid Res. 2012
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Orthologous Events
PCSK9:LDLR bind to Clathrin (Mus musculus)
PCSK9:LDLR bind to Clathrin (Rattus norvegicus)
PCSK9:LDLR bind to Clathrin (Sus scrofa)
PCSK9:LDLR bind to Clathrin (Xenopus tropicalis)
Authored
Sanchis, A  (2015-05-12)
Reviewed
D'Eustachio, P  (2016-04-20)
Created
Sanchis, A  (2015-06-22)
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