NPPA(124-151) binds NPR1

Stable Identifier
R-HSA-6784598
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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NPPA(124-151) binds NPR1
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Natriuretic peptides A (NPPA) is a hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. It specifically binds the atrial natriuretic peptide receptor 1 (NPR1) and stimulates its guanylate cyclase activity resulting in cGMP production (Koller et al. 1991, Pandey 2014).

Literature References
PubMed ID Title Journal Year
1672777 Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)

Koller, KJ, Lowe, DG, Bennett, GL, Minamino, N, Kangawa, K, Matsuo, H, Goeddel, DV

Science 1991
25202235 Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca(2+) release, and activation of protein kinase C

Pandey, KN

Front Mol Neurosci 2014
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Participant Of
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Orthologous Events
NPPA(124-151) binds NPR1 (Bos taurus)
NPPA(124-151) binds NPR1 (Canis familiaris)
NPPA(124-151) binds NPR1 (Gallus gallus)
NPPA(124-151) binds NPR1 (Mus musculus)
NPPA(124-151) binds NPR1 (Rattus norvegicus)
NPPA(124-151) binds NPR1 (Xenopus tropicalis)
Authored
Jassal, B  (2015-06-22)
Reviewed
Colotti, G  (2015-11-09)
Created
Jassal, B  (2015-06-22)