Reactome | NPPA(124-151) binds NPR1

NPPA(124-151) binds NPR1

Stable Identifier

R-HSA-6784598

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Natriuretic peptides A (NPPA) is a hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. It specifically binds the atrial natriuretic peptide receptor 1 (NPR1) and stimulates its guanylate cyclase activity resulting in cGMP production (Koller et al. 1991, Pandey 2014).

Literature References

PubMed ID	Title	Journal	Year
1672777	Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP) Koller, KJ, Lowe, DG, Bennett, GL, Minamino, N, Kangawa, K, Matsuo, H, Goeddel, DV	Science	1991
25202235	Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca(2+) release, and activation of protein kinase C Pandey, KN	Front Mol Neurosci	2014