Reactome | TP53RK [nucleoplasm]

TP53RK [nucleoplasm]

Stable Identifier

R-HSA-6784489

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TP53-regulating kinase ecNumber2.7.11.1/ecNumber, PRPK_HUMAN

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        TP53RK phosphorylates TP53 (Homo sapiens)
        
        TP53RK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96S44 TP53RK

Gene Names

TP53RK, C20orf64, PRPK

Chain

chain:1-253

Reference Genes

BioGPS Gene:112858 TP53RK

COSMIC (genes):TP53RK TP53RK

CTD Gene:112858 TP53RK

dbSNP Gene:112858 TP53RK

ENSEMBL:ENSG00000172315 TP53RK

HGNC:16197 TP53RK

KEGG:hsa:112858 TP53RK

Monarch:112858 TP53RK

NCBI Gene:112858 TP53RK

OMIM:608679 TP53RK

UCSC:Q96S44 TP53RK

Reference Transcript

RefSeq:NM_033550.3 TP53RK

Other Identifiers

112858

11721485_at

11721486_at

11721487_s_at

16919906

225402_PM_at

225402_at

235192_PM_at

235192_at

3908051

3908053

3908054

3908055

3908056

3908057

46623_at

51887_at

75195_at

8066776

89931_at

A_23_P109055

A_24_P245646

A_33_P3391656

GE80575

GO:0000408

GO:0002039

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006399

GO:0006468

GO:0008033

GO:0016301

GO:0016740

GO:0016787

GO:0043226

GO:0070525

GO:0106310

GO:0140096

GO:1901796

HMNXSV003041868

Hs.121031.0.S1_3p_at

Hs.282990.0.S1_3p_at

ILMN_1764851

PH_hs_0025775

TC20000906.hg

Participates

as a component of

KEOPS complex [nucleoplasm] (Homo sapiens)

Inferred To

Tp53rkb [nucleoplasm] (Rattus norvegicus)

Homologues of TP53RK [nucleoplasm] (Rattus norvegicus)

Tp53rka [nucleoplasm] (Rattus norvegicus)

TP53RK [nucleoplasm] (Bos taurus)

TP53RK [nucleoplasm] (Canis familiaris)

TP53RK [nucleoplasm] (Mus musculus)

TP53RK [nucleoplasm] (Sus scrofa)

Tcs5 [nucleoplasm] (Drosophila melanogaster)

tp53rk [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_291028.3

Guide to Pharmacology - Targets

2248

ENSEMBL

ENSP00000361186, ENST00000372114, ENSG00000172315

OpenTargets

ENSG00000172315

PRO

Q96S44

GlyGen

Q96S44

PDB

7SZB, 6WQX, 7SZA, 7SZC, 7SZD

IntEnz

2.7.11.1

GeneCards

TP53RK

HPA

ENSG00000172315-TP53RK

Pharos - Targets

Q96S44

Orphanet

TP53RK

HMDB Protein

HMDBP01341

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C4 TPRKB	1	TPRKB [nucleoplasm] (R-HSA-6784505)	0.853	7
UniProt:Q9BXV9 C14orf142	1	C14orf142 [nucleoplasm] (R-HSA-9938502)	0.823	7
UniProt:Q9NPF4 OSGEP	1	OSGEP [nucleoplasm] (R-HSA-6784522)	0.798	6
UniProt:Q13137 CACO2			0.742	5
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.643	3
UniProt:Q14657 LAGE3	1	LAGE3 [nucleoplasm] (R-HSA-6784525)	0.643	4
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	3
UniProt:Q9GZZ9 UBA5	1	UBA5 [cytosol] (R-HSA-947700)	0.527	2
UniProt:Q9Y6G5 COMMD10	2	COMMD10 [nucleoplasm] (R-HSA-8955101) COMMD10 [cytosol] (R-HSA-8955105)	0.527	2