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Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde
Stable Identifier
R-HSA-6784402
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
1-pyrroline-3-hydroxy-5-carboxylate + H2O => 4-OH-L-glutamate semialdehyde
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to form 4-OH-L-glutamate semialdehyde is inferred from the behavior of the analogous intermediate of proline catabolism (Moxley et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
22040654
Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli
Tanner, JJ
,
Becker, DF
,
Moxley, MA
Arch. Biochem. Biophys.
2011
Participants
Input
1-pyrroline-3-hydroxy-5-carboxylate [mitochondrial matrix]
H2O [mitochondrial matrix]
Output
4-OH-L-Glu semialdehyde [mitochondrial matrix]
Participates
as an event of
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Event Information
Go Biological Process
glyoxylate metabolic process (0046487)
Authored
D'Eustachio, P (2015-06-19)
Reviewed
Jassal, B (2016-12-23)
Created
D'Eustachio, P (2015-06-19)
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