Reactome | Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde

Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde

Stable Identifier

R-HSA-6784402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

1-pyrroline-3-hydroxy-5-carboxylate + H2O => 4-OH-L-glutamate semialdehyde

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Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde

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The spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to form 4-OH-L-glutamate semialdehyde is inferred from the behavior of the analogous intermediate of proline catabolism (Moxley et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22040654	Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli Moxley, MA, Tanner, JJ, Becker, DF	Arch. Biochem. Biophys.	2011