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HOGA1 [mitochondrial matrix]
Stable Identifier
R-HSA-6784397
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)
HOGA1 tetramer [mitochondrial matrix] (Homo sapiens)
HOGA1 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21998747
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria
Knight, J
,
Holmes, RP
,
Hantgan, RR
,
Johnson, LC
,
Riedel, TJ
,
Lowther, WT
PLoS ONE
2011
External Reference Information
External Reference
UniProt:Q86XE5 HOGA1
Gene Names
HOGA1, C10orf65, DHDPSL
Chain
transit peptide:1-25, chain:26-327
Reference Genes
BioGPS Gene:112817 HOGA1
COSMIC (genes):HOGA1 HOGA1
CTD Gene:112817 HOGA1
dbSNP Gene:112817 HOGA1
ENSEMBL:ENSG00000241935 HOGA1
ENSEMBL_homo_sapiens_GENE:ENSG00000241935.9 HOGA1
HGNC:25155 HOGA1
KEGG Gene (Homo sapiens):112817 HOGA1
Monarch:112817 HOGA1
NCBI Gene:112817 HOGA1
OMIM:613597 HOGA1
UCSC:Q86XE5 HOGA1
Reference Transcript
RefSeq:NM_138413.3 HOGA1
RefSeq:NM_001134670.1 HOGA1
Other Identifiers
112817
11731830_a_at
11731831_x_at
16708020
239093_PM_at
239093_at
3259938
3259939
3259940
3259941
3259943
3259944
3259946
3259949
3259952
3259956
3259957
3259958
50566_at
7929664
A_23_P364613
GE80110
GO:0003824
GO:0005515
GO:0005739
GO:0005759
GO:0006520
GO:0006575
GO:0008700
GO:0008747
GO:0009436
GO:0016829
GO:0016833
GO:0019262
GO:0019470
GO:0033609
GO:0042803
GO:0042866
GO:0043226
GO:0046487
GO:0106009
GO:1901135
HMNXSV003053133
Hs.121528.0.A1_3p_at
Hs.121528.0.A1_3p_x_at
ILMN_1777591
PH_hs_0025064
TC10002957.hg
Participates
as a component of
HOGA1 tetramer [mitochondrial matrix] (Homo sapiens)
Inferred To
HOGA1 [mitochondrial matrix]
(Bos taurus)
HOGA1 [mitochondrial matrix]
(Canis familiaris)
HOGA1 [mitochondrial matrix]
(Danio rerio)
HOGA1 [mitochondrial matrix]
(Gallus gallus)
HOGA1 [mitochondrial matrix]
(Mus musculus)
HOGA1 [mitochondrial matrix]
(Rattus norvegicus)
HOGA1 [mitochondrial matrix]
(Sus scrofa)
HOGA1 [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_612422.2
,
NP_001128142.1
OpenTargets
ENSG00000241935
GeneCards
Q86XE5
HPA
ENSG00000241935-HOGA1
Ensembl
ENSP00000359681
,
ENST00000370646
,
ENSP00000359680
,
ENSG00000241935
,
ENST00000370647
PRO
Q86XE5
Pharos - Targets
Q86XE5
Orphanet
19460
HMDB Protein
HMDBP11784
PDB
3S5O
,
3S5N
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQZ5 STARD7
3
pre-STARD7 [mitochondrial intermembrane space]
(R-HSA-9839780)
cytosolic STARD7 [mitochondrial outer membrane]
(R-HSA-9856506)
mito-STARD7 [mitochondrial outer membrane]
(R-HSA-8873841)
0.499
2
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