Reactome | p-Y-TYK2 [cytosol]

p-Y-TYK2 [cytosol]

Stable Identifier

R-HSA-6784366

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-10 signaling (Homo sapiens)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
        
        2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
        
        2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - Interleukin-23 signaling (Homo sapiens)
        
        IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
        
        IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
        
        IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - p-Y-STATs dissociate (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29597 TYK2

Gene Names

TYK2

Chain

chain:1-1187

Reference Genes

BioGPS Gene:7297 TYK2

COSMIC (genes):TYK2 TYK2

CTD Gene:7297 TYK2

dbSNP Gene:7297 TYK2

ENSEMBL:ENSG00000105397 TYK2

ENSEMBL_homo_sapiens_GENE:ENSG00000105397 TYK2

HGNC:12440 TYK2

KEGG Gene (Homo sapiens):7297 TYK2

Monarch:7297 TYK2

NCBI Gene:7297 TYK2

OMIM:176941 TYK2

UCSC:P29597 TYK2

Reference Transcript

Other Identifiers

0001980068

04660+2.7.10.2

11757379_a_at

16868689

205546_s_at

3850281

3850282

3850284

3850288

3850290

3850292

3850294

3850295

3850296

3850298

3850300

3850301

3850302

3850304

3850307

3850308

3850309

3850310

3850311

3850313

3850314

3850315

3850316

3850317

3850318

3850319

3850320

3850321

3850325

3850326

3850327

3850328

3LXN

3LXP

3NYX

3NZ0

3ZON

4GFO

4GIH

4GII

4GJ2

4GJ3

4GVJ

4OLI

4PO6

4PY1

4WOV

5157

5C01

5C03

5F1Z

5F20

5TKD

5WAL

7297

8033996

993_at

A0A024R7E4

A_23_P153311

AAH14243

AAS37680

AY549314

BC014243

CAA38449

CCDS12236

CH471106

E9PM19

E9PPF2

E9PQL2

EAW84099

EAW84100

ENSG00000105397

ENSP00000264818

ENSP00000431885

ENST00000264818

ENST00000525621

EntrezGene:7297

g4507748_3p_a_at

GE59795

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0008150

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0031702

GO:0035556

GO:0035722

GO:0038155

GO:0043167

GO:0043226

GO:0060337

GO:0070062

GO:0070106

HGNC:12440

HPA005157

ILMN_1676955

IPR000299

IPR000719

IPR000980

IPR001245

IPR008266

IPR011009

IPR016045

IPR016251

IPR017441

IPR019749

IPR020635

IPR035963

IPR036860

K7EJR6

LRG_121

MIM:176941

MIM:611521

NM_003331

NP_003322

PF07714

PH_hs_0004337

PR00109

PR01823

PR01827

SM00219

SM00252

SM00295

TC19001164.hg

TYK2

TYK2-201

TYK2-205

uc002moc.5

uc060thj.1

UPI000013D573

X54637

X54637_at

XM_011528245

XM_011528246

XM_011528247

XP_011526547

XP_011526548

XP_011526549

XR_001753750

XR_001753751

Participant Of

hasMember

p-Y1007-JAK2,p-Y-TYK2 [cytosol]

hasComponent

Other forms of this molecule

p-TYK2 [cytosol]

TYK2 [cytosol]

p-Y1054,Y1055-TYK2 [cytosol]

p-Y1054-TYK2 [cytosol]

Inferred To

Homologues of p-Y-TYK2 [cytosol] (Gallus gallus)

Homologues of p-Y-TYK2 [cytosol] (Sus scrofa)

phospho-p-Y-TYK2 [cytosol] (Bos taurus)

phospho-p-Y-TYK2 [cytosol] (Canis familiaris)

phospho-p-Y-TYK2 [cytosol] (Danio rerio)

phospho-p-Y-TYK2 [cytosol] (Gallus gallus)

phospho-p-Y-TYK2 [cytosol] (Mus musculus)

phospho-p-Y-TYK2 [cytosol] (Rattus norvegicus)

phospho-p-Y-TYK2 [cytosol] (Sus scrofa)

phospho-p-Y-TYK2 [cytosol] (Xenopus tropicalis)

Ghost homologue of p-Y-TYK2 [cytosol] (Taeniopygia guttata)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003322.3, XP_011526547.1

ZINC - World Drugs

TYK2_HUMAN

OpenTargets

ENSG00000105397

ZINC - FDA approved

TYK2_HUMAN

ZINC - Substances

TYK2_HUMAN

ZINC target

P29597

PRO

P29597

PDB

5C03, 3LXP, 5TKD, 4GIH, 5WAL, 4GFO, 3ZON, 5C01, 6DBM, 4GJ3, 6DBK, 3LXN, 4GVJ, 4PY1, 3NZ0, 4OLI, 3NYX, 4GII, 5F1Z, 4PO6, 4GJ2, 4WOV, 5F20, 6AAM

GeneCards

P29597

DOCK Blaster

4GIH, 5F1Z, 4GII, 3NZ0, 4OLI, 4GJ2, 5C03, 4GFO, 5C01, 3NYX, 5F20, 3LXP, 3LXN, 5TKD, 3ZON, 4GJ3, 4PO6, 4WOV, 4GVJ, 4PY1

BRENDA (Homo sapiens)

2.7.10.2

Orphanet

17260

ZINC - Predictions - Purchasable

TYK2_HUMAN

HMDB Protein

HMDBP01375

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2	2	p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031) KHDRBS2 [nucleoplasm] (R-HSA-8849028)	0.764	6
UniProt:Q13643 FHL3			0.696	5
UniProt:P17181-1 IFNAR1			0.558	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.556	3
UniProt:P06463 VE6			0.524	4
UniProt:P04019 VE6			0.524	3
UniProt:P08238 HSP90AB1	5	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.524	2
UniProt:P61978-2 HNRNPK			0.488	2
UniProt:Q9NQX1-2 PRDM5			0.488	2
IntAct:EBI-17198574 KRTAP63			0.488	2
UniProt:A6NEM1 GG6L9			0.488	2
UniProt:Q05BL1 Q05BL1			0.488	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.488	2
UniProt:A8MQ03 CRTP1			0.488	2
UniProt:O75525 KHDRBS3	2	p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035) KHDRSB3 [nucleoplasm] (R-HSA-8849040)	0.488	2