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p-Y-TYK2 [cytosol]
Stable Identifier
R-HSA-6784366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
p-Y-STATs dissociate (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
p-Y-TYK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29597 TYK2
Gene Names
TYK2
Chain
chain:1-1187
Reference Genes
BioGPS Gene:7297 TYK2
COSMIC (genes):TYK2 TYK2
CTD Gene:7297 TYK2
dbSNP Gene:7297 TYK2
ENSEMBL:ENSG00000105397 TYK2
ENSEMBL_homo_sapiens_GENE:ENSG00000105397 TYK2
HGNC:12440 TYK2
KEGG Gene (Homo sapiens):7297 TYK2
Monarch:7297 TYK2
NCBI Gene:7297 TYK2
OMIM:176941 TYK2
UCSC:P29597 TYK2
Reference Transcript
RefSeq:XM_011528245.1 TYK2
RefSeq:NM_003331.4 TYK2
Other Identifiers
0001980068
04660+2.7.10.2
11757379_a_at
16868689
205546_s_at
3850281
3850282
3850284
3850288
3850290
3850292
3850294
3850295
3850296
3850298
3850300
3850301
3850302
3850304
3850307
3850308
3850309
3850310
3850311
3850313
3850314
3850315
3850316
3850317
3850318
3850319
3850320
3850321
3850325
3850326
3850327
3850328
3LXN
3LXP
3NYX
3NZ0
3ZON
4GFO
4GIH
4GII
4GJ2
4GJ3
4GVJ
4OLI
4PO6
4PY1
4WOV
5157
5C01
5C03
5F1Z
5F20
5TKD
5WAL
7297
8033996
993_at
A0A024R7E4
A_23_P153311
AAH14243
AAS37680
AY549314
BC014243
CAA38449
CCDS12236
CH471106
E9PM19
E9PPF2
E9PQL2
EAW84099
EAW84100
ENSG00000105397
ENSP00000264818
ENSP00000431885
ENST00000264818
ENST00000525621
EntrezGene:7297
g4507748_3p_a_at
GE59795
GO:0000166
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0008150
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0031702
GO:0035556
GO:0035722
GO:0038155
GO:0043167
GO:0043226
GO:0060337
GO:0070062
GO:0070106
HGNC:12440
HPA005157
ILMN_1676955
IPR000299
IPR000719
IPR000980
IPR001245
IPR008266
IPR011009
IPR016045
IPR016251
IPR017441
IPR019749
IPR020635
IPR035963
IPR036860
K7EJR6
LRG_121
MIM:176941
MIM:611521
NM_003331
NP_003322
PF07714
PH_hs_0004337
PR00109
PR01823
PR01827
SM00219
SM00252
SM00295
TC19001164.hg
TYK2
TYK2-201
TYK2-205
uc002moc.5
uc060thj.1
UPI000013D573
X54637
X54637_at
XM_011528245
XM_011528246
XM_011528247
XP_011526547
XP_011526548
XP_011526549
XR_001753750
XR_001753751
Participant Of
hasMember
p-Y1007-JAK2,p-Y-TYK2 [cytosol]
hasComponent
IL10RB:p-Y-TYK2 [plasma membrane]
IL12RB1:p-Y-TYK2 [plasma membrane]
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane]
Other forms of this molecule
p-TYK2 [cytosol]
TYK2 [cytosol]
p-Y1054,Y1055-TYK2 [cytosol]
p-Y1054-TYK2 [cytosol]
Inferred To
Homologues of p-Y-TYK2 [cytosol] (Gallus gallus)
Homologues of p-Y-TYK2 [cytosol] (Sus scrofa)
phospho-p-Y-TYK2 [cytosol] (Bos taurus)
phospho-p-Y-TYK2 [cytosol] (Canis familiaris)
phospho-p-Y-TYK2 [cytosol] (Danio rerio)
phospho-p-Y-TYK2 [cytosol] (Gallus gallus)
phospho-p-Y-TYK2 [cytosol] (Mus musculus)
phospho-p-Y-TYK2 [cytosol] (Rattus norvegicus)
phospho-p-Y-TYK2 [cytosol] (Sus scrofa)
phospho-p-Y-TYK2 [cytosol] (Xenopus tropicalis)
Ghost homologue of p-Y-TYK2 [cytosol] (Taeniopygia guttata)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003322.3
,
XP_011526547.1
ZINC - World Drugs
TYK2_HUMAN
OpenTargets
ENSG00000105397
ZINC - FDA approved
TYK2_HUMAN
ZINC - Substances
TYK2_HUMAN
ZINC target
P29597
PRO
P29597
PDB
5C03
,
3LXP
,
5TKD
,
4GIH
,
5WAL
,
4GFO
,
3ZON
,
5C01
,
6DBM
,
4GJ3
,
6DBK
,
3LXN
,
4GVJ
,
4PY1
,
3NZ0
,
4OLI
,
3NYX
,
4GII
,
5F1Z
,
4PO6
,
4GJ2
,
4WOV
,
5F20
,
6AAM
GeneCards
P29597
DOCK Blaster
4GIH
,
5F1Z
,
4GII
,
3NZ0
,
4OLI
,
4GJ2
,
5C03
,
4GFO
,
5C01
,
3NYX
,
5F20
,
3LXP
,
3LXN
,
5TKD
,
3ZON
,
4GJ3
,
4PO6
,
4WOV
,
4GVJ
,
4PY1
BRENDA (Homo sapiens)
2.7.10.2
Orphanet
17260
ZINC - Predictions - Purchasable
TYK2_HUMAN
HMDB Protein
HMDBP01375
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2
2
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
0.764
6
UniProt:Q13643 FHL3
0.696
5
UniProt:P17181-1 IFNAR1
0.558
3
UniProt:Q9BUZ4 TRAF4
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:P61978 HNRNPK
2
SUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.556
3
UniProt:P06463 VE6
0.524
4
UniProt:P04019 VE6
0.524
3
UniProt:P08238 HSP90AB1
5
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
0.524
2
UniProt:P61978-2 HNRNPK
0.488
2
UniProt:Q9NQX1-2 PRDM5
0.488
2
IntAct:EBI-17198574 KRTAP63
0.488
2
UniProt:A6NEM1 GG6L9
0.488
2
UniProt:Q05BL1 Q05BL1
0.488
2
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.488
2
UniProt:A8MQ03 CRTP1
0.488
2
UniProt:O75525 KHDRBS3
2
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
0.488
2
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