Reactome | p-Y-TYK2 [cytosol]

p-Y-TYK2 [cytosol]

Stable Identifier

R-HSA-6784366

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-10 signaling (Homo sapiens)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
        
        2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
        
        2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - Interleukin-23 signaling (Homo sapiens)
        
        IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
        
        IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
        
        IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
        
        IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
      - p-Y-STATs dissociate (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)
        
        IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y-TYK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29597 TYK2

Gene Names

TYK2

Chain

chain:1-1187

Reference Genes

BioGPS Gene:7297 TYK2

COSMIC (genes):TYK2 TYK2

CTD Gene:7297 TYK2

dbSNP Gene:7297 TYK2

ENSEMBL:ENSG00000105397 TYK2

HGNC:12440 TYK2

KEGG Gene (Homo sapiens):7297 TYK2

Monarch:7297 TYK2

NCBI Gene:7297 TYK2

OMIM:176941 TYK2

UCSC:P29597 TYK2

Reference Transcript

Other Identifiers

0001980068

11757379_a_at

16868689

205546_s_at

3850280

3850281

3850282

3850284

3850288

3850290

3850292

3850294

3850295

3850296

3850298

3850300

3850301

3850302

3850304

3850307

3850308

3850309

3850310

3850311

3850313

3850314

3850315

3850316

3850317

3850318

3850319

3850320

3850321

3850325

3850326

3850327

3850328

7297

8033996

993_at

A_23_P153311

GE59795

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0008150

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0031702

GO:0035556

GO:0035722

GO:0038155

GO:0043167

GO:0043226

GO:0060337

GO:0070062

GO:0070106

HMNXSV003025674

ILMN_1676955

PH_hs_0004337

TC19001164.hg

X54637_at

g4507748_3p_a_at

Participates

as a component of

as a member of

p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-TYK2 [cytosol]

TYK2 [cytosol]

p-Y1054,Y1055-TYK2 [cytosol]

p-Y1054-TYK2 [cytosol]

Inferred To

phospho-TYK2 [cytosol] (Bos taurus)

phospho-TYK2 [cytosol] (Canis familiaris)

phospho-TYK2 [cytosol] (Gallus gallus)

phospho-TYK2 [cytosol] (Sus scrofa)

phospho-p-Y-TYK2 [cytosol] (Xenopus tropicalis)

phospho-tyk2 [cytosol] (Danio rerio)

phospho-Tyk2 [cytosol] (Mus musculus)

phospho-Tyk2 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011526547.1, NP_003322.3

ZINC - World Drugs

TYK2_HUMAN

Guide to Pharmacology - Targets

2269

OpenTargets

ENSG00000105397

ZINC - FDA approved

TYK2_HUMAN

ZINC - Substances

TYK2_HUMAN

ZINC - Biogenic

TYK2_HUMAN

ZINC target

P29597

PRO

P29597

PDB

7K7Q, 4OLI, 4GII, 6DBK, 5F20, 5F1Z, 6NZF, 4WOV, 7K7O, 6NZE, 4GIH, 6X8G, 5TKD, 5C03, 4GVJ, 6X8F, 5C01, 6NZR, 6OVA, 4GFO, 6NSL, 3ZON, 6VNY, 6NZQ, 6VNX, 6NZP, 6AAM, 4GJ3, 3LXP, 6VNV, 4PO6, 4GJ2, 7AX4, 3LXN, 5WAL, 4PY1, 3NZ0, 6DBM, 3NYX, 6NZH, 6VNS

ZINC - Investigational

TYK2_HUMAN

HPA

ENSG00000105397-TYK2

GeneCards

P29597

Ensembl

ENST00000264818, ENSP00000431885, ENSP00000264818, ENSG00000105397, ENST00000525621

Pharos - Targets

P29597

Orphanet

17260

ZINC - Predictions - Purchasable

TYK2_HUMAN

HMDB Protein

HMDBP01375

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.781	7
UniProt:Q13643 FHL3			0.718	6
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.666	4
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.641	4
UniProt:P17181-1 IFNAR1			0.558	3
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:Q9NQX1-2 PRDM5			0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:O95994 AGR2			0.556	5
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
IntAct:EBI-22311199 CCSB ORF ID			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9ULX6 AKP8L			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P06463 VE6			0.524	4
UniProt:P04019 VE6			0.524	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2

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