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IL10RB:TYK2 [plasma membrane]
Stable Identifier
R-HSA-6784360
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB binds TYK2 (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)
IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
Other interleukin signaling (Homo sapiens)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10RB:TYK2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25004819
The molecular basis of IL-10 function: from receptor structure to the onset of signaling
Walter, MR
Curr. Top. Microbiol. Immunol.
2014
Participants
components
IL10RB [plasma membrane]
(Homo sapiens)
TYK2 [cytosol]
(Homo sapiens)
Participates
as a component of
IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
as an input of
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
as an output of
IL10RB binds TYK2 (Homo sapiens)
Inferred To
IL10RB:TYK2 [plasma membrane]
(Bos taurus)
IL10RB:TYK2 [plasma membrane]
(Canis familiaris)
IL10RB:TYK2 [plasma membrane]
(Danio rerio)
IL10RB:TYK2 [plasma membrane]
(Gallus gallus)
IL10RB:TYK2 [plasma membrane]
(Mus musculus)
IL10RB:TYK2 [plasma membrane]
(Rattus norvegicus)
IL10RB:TYK2 [plasma membrane]
(Sus scrofa)
IL10RB:TYK2 [plasma membrane]
(Xenopus tropicalis)
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