Reactome | PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Stable Identifier

R-HSA-6783955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+), (S)-1-pyrroline-5-carboxylate + NADPH + H+ => L-Pro + NADP+

ReviewStatus

5/5

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PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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Cytosolic pyrroline-5-carboxylate reductase 3 (PYCR3) (also known as Pyrroline-5-carboxylate reductase-like (PYCRL)) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADPH + H+ to form proline and NADP+ (De Ingeniis et al. 2012). Distinct roles have been suggested for PYCR3 versus PYCR1 and 2 enzymes in proline synthesis in melanoma cell lines (De Ingeniis et al. 2012); the physiological role of PYCR3 in normal tissue is less clear.

Literature References

PubMed ID	Title	Journal	Year
23024808	Functional specialization in proline biosynthesis of melanoma Aza-Blanc, P, Scott, DA, Smith, JW, Osterman, AL, De, SK, Ratnikov, B, Ronai, Z, De Ingeniis, J, Richardson, AD, Kazanov, M, Pellecchia, M	PLoS ONE	2012
2722838	Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. Phang, JM, Merrill, MJ, Yeh, GC	J Biol Chem	1989