Reactome | PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Stable Identifier

R-HSA-6783955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+), (S)-1-pyrroline-5-carboxylate + NADPH + H+ => L-Pro + NADP+

ReviewStatus

5/5

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PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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Cytosolic pyrroline-5-carboxylate reductase 3 (PYCR3) (also known as Pyrroline-5-carboxylate reductase-like (PYCRL)) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADPH + H+ to form proline and NADP+ (De Ingeniis et al. 2012). Distinct roles have been suggested for PYCR3 versus PYCR1 and 2 enzymes in proline synthesis in melanoma cell lines (De Ingeniis et al. 2012); the physiological role of PYCR3 in normal tissue is less clear.

Literature References

PubMed ID	Title	Journal	Year
23024808	Functional specialization in proline biosynthesis of melanoma De Ingeniis, J, Ratnikov, B, Richardson, AD, Scott, DA, Aza-Blanc, P, De, SK, Kazanov, M, Pellecchia, M, Ronai, Z, Osterman, AL, Smith, JW	PLoS ONE	2012
2722838	Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. Merrill, MJ, Yeh, GC, Phang, JM	J Biol Chem	1989