PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Stable Identifier
R-HSA-6783955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(S)-1-pyrroline-5-carboxylate + NADPH + H+ => L-Pro + NADP+
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Pyrroline-5-carboxylate reductase-like (PYCRL) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADPH + H+ to form proline and NADP+ in the cytosol (De Ingeniis et al. 2012). While the pyrroline-5-carboxylate reductase described by Merrill et al. (1989) is taken to be the PYCR1 or PYCR2 gene product, its abundance in red blood cell cytosol and its strong preference for NADP as a cofactor suggest the alternative interpretation that it is the product of PYCRL.

Literature References
PubMed ID Title Journal Year
2722838 Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.

Merrill, MJ, Yeh, GC, Phang, JM

J Biol Chem 1989
23024808 Functional specialization in proline biosynthesis of melanoma

De Ingeniis, J, Ratnikov, B, Richardson, AD, Scott, DA, Aza-Blanc, P, De, SK, Kazanov, M, Pellecchia, M, Ronai, Z, Osterman, AL, Smith, JW

PLoS ONE 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
pyrroline-5-carboxylate reductase activity of PYCRL decamer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created