PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Stable Identifier
R-HSA-6783955
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(S)-1-pyrroline-5-carboxylate + NADPH + H+ => L-Pro + NADP+
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Pyrroline-5-carboxylate reductase-like (PYCRL) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADPH + H+ to form proline and NADP+ in the cytosol (De Ingeniis et al. 2012). While the pyrroline-5-carboxylate reductase described by Merrill et al. (1989) is taken to be the PYCR1 or PYCR2 gene product, its abundance in red blood cell cytosol and its strong preference for NADP as a cofactor suggest the alternative interpretation that it is the product of PYCRL.

Literature References
PubMed ID Title Journal Year
23024808 Functional specialization in proline biosynthesis of melanoma

Aza-Blanc, P, Scott, DA, Smith, JW, Osterman, AL, De, SK, Ratnikov, B, Ronai, Z, De Ingeniis, J, Richardson, AD, Kazanov, M, Pellecchia, M

PLoS ONE 2012
2722838 Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.

Phang, JM, Merrill, MJ, Yeh, GC

J Biol Chem 1989
Participants
Participates
Catalyst Activity

pyrroline-5-carboxylate reductase activity of PYCRL decamer [cytosol]

Orthologous Events
Authored
Reviewed
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