Reactome | PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Stable Identifier

R-HSA-6783955

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(S)-1-pyrroline-5-carboxylate + NADPH + H+ => L-Pro + NADP+

ReviewStatus

5/5

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PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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Pyrroline-5-carboxylate reductase-like (PYCRL) catalyzes the reaction of (S)-1-pyrroline-5-carboxylate with NADPH + H+ to form proline and NADP+ in the cytosol (De Ingeniis et al. 2012). While the pyrroline-5-carboxylate reductase described by Merrill et al. (1989) is taken to be the PYCR1 or PYCR2 gene product, its abundance in red blood cell cytosol and its strong preference for NADP as a cofactor suggest the alternative interpretation that it is the product of PYCRL.

Literature References

PubMed ID	Title	Journal	Year
23024808	Functional specialization in proline biosynthesis of melanoma Aza-Blanc, P, Scott, DA, Smith, JW, Osterman, AL, De, SK, Ratnikov, B, Ronai, Z, De Ingeniis, J, Richardson, AD, Kazanov, M, Pellecchia, M	PLoS ONE	2012
2722838	Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. Phang, JM, Merrill, MJ, Yeh, GC	J Biol Chem	1989