P6C transforms to 2AMAS

Stable Identifier
R-HSA-6783883
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, peroxisomal matrix
Synonyms
H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate
ReviewStatus
5/5
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P6C transforms to 2AMAS
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The saccharopine pathway is the predominant lysine degradative pathway in extracerebral tissues, whereas the pipecolate pathway predominates in adult brain. (S)-1-piperideine-6-carboxylate (P6C), an intermediate of the pipecolate pathway, is in equilibrium with alpha-aminoadipate delta-semialdehyde (2AMAS), an intermediate of the saccharopine pathway, so its spontaneous formation can connect the two degradative pathways (Hallen et al. 2013).
Literature References
PubMed ID Title Journal Year
24043460 Lysine metabolism in mammalian brain: an update on the importance of recent discoveries

Hallen, A, Jamie, JF, Cooper, AJ

Amino Acids 2013
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Cross References
RHEA
Authored
Jassal, B  (2015-06-17)
Reviewed
D'Eustachio, P  (2015-06-26)
D'Eustachio, P  (2024-11-08)
Hill, DP  (2025-08-14)
Created
Jassal, B  (2015-06-17)
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