TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)

Stable Identifier
R-HSA-6783492
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The TRMT6:TRMT61A complex transfers a methyl group from S-adenosylmethionine to the 1 position of adenosine-58 of tRNA(Met) (Ozanick et al. 2005). Based on the location of the homologous complex (GCD10:GCD14) in yeast (Anderson et al. 1998), methylation by the TRMT6:TRMT61A complex is inferred to occur in the nucleus.

Literature References
PubMed ID Title Journal Year
9851972 The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA

Anderson, J, Phan, L, Cuesta, R, Carlson, BA, Pak, M, Asano, K, Björk, GR, Tamame, M, Hinnebusch, AG

Genes Dev. 1998
16043508 The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans

Ozanick, S, Krecic, A, Andersland, J, Anderson, JT

RNA 2005
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Catalyst Activity
Title
tRNA (adenine-N1-)-methyltransferase activity of TRMT6:TRMT61A [nucleoplasm]
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