TYW5 uses 2-oxoglutarate and molecular oxygen to hydroxylate yW-72 (7-(3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding OHyW-72 (7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine), carbon dioxide, and succinate (Noma et al. 2010, Kato et al. 2011).
Suzuki, T, Noma, A, Kato, M, Nureki, O, Nagao, A, Ishitani, R
Suzuki, T, Noma, A, Araiso, Y, Kato, M, Nureki, O, Nagao, A, Ishitani, R
2-oxoglutarate-dependent dioxygenase activity of TYW5:Fe2+ dimer [cytoplasm]
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