TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6783455
Type
Reaction [transition]
Species
Homo sapiens
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TYW5 uses 2-oxoglutarate and molecular oxygen to hydroxylate yW-72 (7-(3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding OHyW-72 (7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine), carbon dioxide, and succinate (Noma et al. 2010, Kato et al. 2011).

Literature References
PubMed ID Title Journal Year
20972222 Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification

Kato, M, Araiso, Y, Noma, A, Nagao, A, Suzuki, T, Ishitani, R, Nureki, O

Nucleic Acids Res. 2011
20739293 Expanding role of the jumonji C domain as an RNA hydroxylase

Noma, A, Ishitani, R, Kato, M, Nagao, A, Nureki, O, Suzuki, T

J. Biol. Chem. 2010
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Catalyst Activity
Title
2-oxoglutarate-dependent dioxygenase activity of TYW5:Fe2+ dimer [cytoplasm]
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