TYW5 uses 2-oxoglutarate and molecular oxygen to hydroxylate yW-72 (7-(3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding OHyW-72 (7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine), carbon dioxide, and succinate (Noma et al. 2010, Kato et al. 2011).
Kato, M, Araiso, Y, Noma, A, Nagao, A, Suzuki, T, Ishitani, R, Nureki, O
Noma, A, Ishitani, R, Kato, M, Nagao, A, Nureki, O, Suzuki, T
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