Reactome | APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region

APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region

Stable Identifier

R-HSA-6783332

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endosome lumen, extracellular region

ReviewStatus

5/5

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APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region

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The Abeta peptides 42 and 40 (APP(672-713) and APP(673-711) respectively) are thought to be the main fibril-forming peptides implicated in neurodegenerative disorders. They translocate from the endosomal lumen to the extracellular region by an unknown mechanism (Qui et al. 2015, Baranello et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26018760	Aβ42 and Aβ40: similarities and differences Liu, Q, Qiu, T, Zhao, YF, Chen, YX, Li, YM	J. Pept. Sci.	2015
25523424	Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease Padmaraju, V, Lahiri, DK, Chopra, N, Sambamurti, K, Baranello, RJ, Pappolla, MA, Greig, NH, Bharani, KL	Curr Alzheimer Res	2015