APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region

Stable Identifier
R-HSA-6783332
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endosome lumen, extracellular region
ReviewStatus
5/5
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APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region
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The Abeta peptides 42 and 40 (APP(672-713) and APP(673-711) respectively) are thought to be the main fibril-forming peptides implicated in neurodegenerative disorders. They translocate from the endosomal lumen to the extracellular region by an unknown mechanism (Qui et al. 2015, Baranello et al. 2015).

Literature References
PubMed ID Title Journal Year
26018760 Aβ42 and Aβ40: similarities and differences

Liu, Q, Qiu, T, Zhao, YF, Chen, YX, Li, YM

J. Pept. Sci. 2015
25523424 Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

Padmaraju, V, Lahiri, DK, Chopra, N, Sambamurti, K, Baranello, RJ, Pappolla, MA, Greig, NH, Bharani, KL

Curr Alzheimer Res 2015
Participants
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Output
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Authored
Jassal, B  (2015-06-12)
Reviewed
D'Eustachio, P  (2015-06-26)
Perry, G  (2015-11-09)
Created
Jassal, B  (2015-06-12)
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