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K63polyUb-HIST1H2AB [nucleoplasm]
Stable Identifier
R-HSA-6783287
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HIST1H2AB
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Homo sapiens)
K63polyUb-histone H2A [nucleoplasm] (Homo sapiens)
K63polyUb-histone HIST1H2A [nucleoplasm] (Homo sapiens)
K63polyUb-HIST1H2AB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04908 H2AC4
Gene Names
H2AC4, H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE
Chain
initiator methionine:, chain:2-130
Reference Genes
BioGPS Gene:3012 H2AC4
BioGPS Gene:8335 H2AC4
CTD Gene:3012 H2AC4
CTD Gene:8335 H2AC4
dbSNP Gene:3012 H2AC4
dbSNP Gene:8335 H2AC4
ENSEMBL:ENSG00000277075 HIST1H2AE
ENSEMBL:ENSG00000278463 HIST1H2AB
ENSEMBL_homo_sapiens_GENE:ENSG00000277075.3 H2AC4
ENSEMBL_homo_sapiens_GENE:ENSG00000278463.2 H2AC4
HGNC:4724 H2AC4
HGNC:4734 H2AC4
KEGG Gene (Homo sapiens):3012 H2AC4
KEGG Gene (Homo sapiens):8335 H2AC4
Monarch:3012 H2AC4
Monarch:8335 H2AC4
NCBI Gene:3012 H2AC4
NCBI Gene:8335 H2AC4
OMIM:602786 H2AC4
OMIM:602795 H2AC4
Reference Transcript
RefSeq:NM_021052.2 H2AC4
RefSeq:NM_003513.2 H2AC4
Other Identifiers
11731693_at
11731694_s_at
11741215_at
17005589
17016366
208569_PM_at
208569_at
214469_PM_at
214469_at
2899224
2899225
2899226
2946220
2946221
2946222
2946223
2946224
3012
35127_at
8117408
8124391
8335
A_14_P115530
A_23_P59045
A_24_P223384
GE504811
GE62562
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0006325
GO:0008285
GO:0030527
GO:0043226
GO:0043229
GO:0043505
GO:0046982
GO:0061644
GO:0070062
HMNXSV003010811
HMNXSV003012591
Hs.121017.0.S1_3p_at
ILMN_1753524
ILMN_1756849
M60752_at
PH_hs_0006702
PH_hs_0013174
PH_hs_0032313
TC06000173.hg
TC06001343.hg
Z83741_at
g4504246_3p_at
Participates
as a member of
K63polyUb-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-HIST1H2AB [nucleoplasm]
Ack6-HIST1H2AB [nucleoplasm]
Me2aR30-HIST1H2AB [nucleoplasm]
MeR30-HIST1H2AB [nucleoplasm]
Me2aR4-HIST1H2AB [nucleoplasm]
MeR4-HIST1H2AB [nucleoplasm]
Me2sR4-HIST1H2AB [nucleoplasm]
Me2aR12-HIST1H2AB [nucleoplasm]
MeR12-HIST1H2AB [nucleoplasm]
HIST1H2AB [extracellular region]
Ack-HIST1H2AB [nucleoplasm]
HIST1H2AB [nucleoplasm]
Inferred To
LOC100485548 [nucleoplasm]
(Xenopus tropicalis)
LOC100487632 [nucleoplasm]
(Xenopus tropicalis)
LOC116411633 [nucleoplasm]
(Xenopus tropicalis)
h2ac16 [nucleoplasm]
(Xenopus tropicalis)
H2AC4 [nucleoplasm]
(Canis familiaris)
Hist1h2ap [nucleoplasm]
(Mus musculus)
K63polyUb-HIST1H2AB [nucleoplasm]
(Bos taurus)
K63polyUb-HIST1H2AB [nucleoplasm]
(Gallus gallus)
LOC116407737 [nucleoplasm]
(Xenopus tropicalis)
LOC100487067 [nucleoplasm]
(Xenopus tropicalis)
H2ac4 [nucleoplasm]
(Mus musculus)
Homologues of K63polyUb-HIST1H2AB [nucleoplasm]
(Mus musculus)
Homologues of K63polyUb-HIST1H2AB [nucleoplasm]
(Xenopus tropicalis)
H2ac6 [nucleoplasm]
(Mus musculus)
Hist1h2an [nucleoplasm]
(Mus musculus)
H2AC8 [nucleoplasm]
(Sus scrofa)
H2ac15 [nucleoplasm]
(Mus musculus)
H2ac10 [nucleoplasm]
(Rattus norvegicus)
Hist1h2ao [nucleoplasm]
(Mus musculus)
H2ac8 [nucleoplasm]
(Mus musculus)
H2ac11 [nucleoplasm]
(Mus musculus)
Hist1h2af [nucleoplasm]
(Mus musculus)
LOC101732059 [nucleoplasm]
(Xenopus tropicalis)
H2ac12 [nucleoplasm]
(Mus musculus)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 120
Coordinate
120
Modification
K63polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_003504.2
,
NP_066390.1
OpenTargets
ENSG00000278463
GeneCards
P04908
HPA
ENSG00000277075-H2AC8
,
ENSG00000278463-H2AC4
Ensembl
ENST00000303910
,
ENSG00000277075
,
ENST00000615868
,
ENSP00000483842
,
ENSP00000303373
,
ENSG00000278463
PRO
P04908
Pharos - Targets
P04908
HMDB Protein
HMDBP07727
PDB
6V92
,
5GXQ
,
6KE9
,
7COW
,
7K5Y
,
7BWD
,
6A5O
,
8U13
,
6T90
,
3AZG
,
8GRM
,
7WBW
,
6HKT
,
6T7D
,
5Z23
,
8IHL
,
7XSX
,
3A6N
,
5B2I
,
6INQ
,
7XVL
,
3AZI
,
7XCT
,
8JNE
,
6ACL
,
7XTI
,
6IPU
,
7PFX
,
3AYW
,
6HTS
,
8YTI
,
6LER
,
6L49
,
7PFA
,
7WBX
,
7PEX
,
5B32
,
7SCZ
,
5AY8
,
8SNA
,
8SN3
,
6R8Z
,
8I17
,
5GSE
,
8UQ9
,
6LE9
,
7PF6
,
8HAN
,
8U14
,
8SMW
,
6J50
,
8JH3
,
6E0P
,
8SN6
,
7PFF
,
2RVQ
,
7PF3
,
7PEY
,
5GTC
,
8JND
,
8HAK
,
6E0C
,
7XSE
,
5B0Z
,
7PF2
,
3W99
,
8WG5
,
5XF5
,
7DBP
,
6R92
,
8HAJ
,
8XBT
,
8JLA
,
5AV5
,
7CCR
,
6LA9
,
3AZN
,
6J51
,
7PFT
,
5Y0C
,
5AV9
,
7PET
,
7V99
,
3AZM
,
7WBV
,
5JRG
,
6R91
,
7PEU
,
7NL0
,
3AV1
,
8TXW
,
5XF3
,
8TXX
,
8OTT
,
7XX6
,
6JXD
,
8JH2
,
6A5U
,
5B2J
,
3WKJ
,
6A5T
,
6BUZ
,
6LAB
,
6JR1
,
7PFW
,
7SCY
,
8IEG
,
3W96
,
3WTP
,
6M3V
,
8HAG
,
8JL9
,
8H0W
,
7LYC
,
6M44
,
7ZI4
,
8UQA
,
8Q3M
,
5AVC
,
8OSK
,
7XX5
,
8Q3E
,
7Y00
,
8SMY
,
7K61
,
3AZJ
,
7V9J
,
8UPF
,
8HE5
,
3X1V
,
7K63
,
8SN8
,
5X7X
,
8SN9
,
7W9V
,
3AZE
,
7K5X
,
7V96
,
3AZF
,
8UQ8
,
6T7B
,
6O1D
,
6JR0
,
5B24
,
6T93
,
6T7C
,
5CPI
,
8JNF
,
5AVB
,
3X1S
,
7PFE
,
6A5P
,
6R8Y
,
7XTD
,
6J4W
,
8JLD
,
8SN0
,
6YOV
,
7BY0
,
7PFV
,
7BXT
,
7PEV
,
8JHG
,
8SN2
,
7XSZ
,
6L4A
,
7PEW
,
6KXV
,
7D1Z
,
7PF5
,
6AEE
,
7C0M
,
7XVM
,
6V2K
,
6A5L
,
8SN4
,
4YM5
,
7V90
,
7VCL
,
8KB5
,
7V9S
,
7XD1
,
5ZBX
,
8JH4
,
5B40
,
8SMX
,
8HAM
,
7PF4
,
6LA8
,
6J4Z
,
8G57
,
8OSJ
,
8HAL
,
8UQD
,
7PFD
,
7PEZ
,
7V9C
,
7XZZ
,
6J4X
,
7PFC
,
5B0Y
,
7PF0
,
8JLB
,
6R93
,
8HAI
,
7XZY
,
5AV6
,
3AZL
,
6R94
,
7CCQ
,
3AZK
,
6R90
,
4YM6
,
7D20
,
4Z5T
,
8XBU
,
5AV8
,
8TXV
,
3W98
,
3AZH
,
8H0V
,
6A5R
,
5XF4
,
6J4Y
,
7V9K
,
3AN2
,
7LYA
,
8UQB
,
7VZ4
,
8SN7
,
8UQC
,
7XCR
,
3AV2
,
6LA2
,
7XZX
,
8IEJ
,
7K60
,
7XT7
,
6L9Z
,
3AFA
,
8HAH
,
5B31
,
5Y0D
,
7LYB
,
6L9H
,
7PFU
,
8HR1
,
6USJ
,
8HQY
,
7XD0
,
8OSL
,
8SN5
,
3W97
,
6IQ4
,
6T7A
,
8OTS
,
8Q3X
,
6IR9
,
5CPK
,
8SMZ
,
8UQE
,
7VA4
,
2CV5
,
7Y7I
,
8SN1
,
6T79
,
8Q36
,
5CPJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.874
12
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.589
2
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