OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1

Stable Identifier
R-HSA-6783238
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

OTUB1 (and OTUB2) can bind the nuclear proteins MDM2 cognate E2 UBE2D1 (Sun et al. 2012), and ESR1 (Stanisic et al. 2009). OTUB1 has DUB activity but mainly acts by suppressing ubiquitin-conjugating E2 enzymes, independently of its catalytic activity (Sun & Dai 2014).

Literature References
PubMed ID Title Journal Year
19383985 OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity

O'Malley, BW, Stanisi?, V, Malovannaya, A, Lonard, DM, Qin, J

J. Biol. Chem. 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Bos taurus)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Danio rerio)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Drosophila melanogaster)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Rattus norvegicus)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)
OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-11)
Cite Us!