TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-HSA-6782895
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasm
ReviewStatus
5/5
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TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
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As inferred from homologs in Saccharomyces cerevisiae, TYW1 in a complex with FMN and an iron-sulfur cluster transfers 2 carbon atoms from pyruvate to 1-methylguanosine-37 of tRNA(Phe), yielding yW-187 (4-demethylwyosine) at nucleotide 37.

Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

lyase activity of TYW1:FMN:4Fe-4S [cytoplasm]

Physical Entity
TYW1:FMN:4Fe-4S [cytoplasm] (Homo sapiens)
Activity
lyase activity (GO:0016829)
Inferred From
TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 at nucleotide 37 of tRNA(Phe) (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-08)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-09)
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