Reactome | K48polyUb-RNF128 [cytosol]

K48polyUb-RNF128 [cytosol]

Stable Identifier

R-HSA-6782813

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase RNF128, RN128_HUMAN, GRAIL

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP8 deubiquitinates RNF128 (Homo sapiens)
        
        USP8:K48polyUb-RNF128:OTUB1 [cytosol] (Homo sapiens)
        
        K48polyUb-RNF128:OTUB1 [cytosol] (Homo sapiens)
        
        K48polyUb-RNF128 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TEB7 RNF128

Gene Names

RNF128

Chain

signal peptide:1-38, chain:39-428

Reference Genes

BioGPS Gene:79589 RNF128

COSMIC (genes):RNF128 RNF128

CTD Gene:79589 RNF128

dbSNP Gene:79589 RNF128

ENSEMBL:ENSG00000133135 RNF128

HGNC:21153 RNF128

KEGG Gene (Homo sapiens):79589 RNF128

Monarch:79589 RNF128

NCBI Gene:79589 RNF128

OMIM:300439 RNF128

UCSC:Q8TEB7 RNF128

Reference Transcript

Other Identifiers

0005360154

0005570167

0005690601

11740782_a_at

17105939

219263_at

3986262

3986263

3986264

3986265

3986266

3986267

3986268

3986269

3986272

3986273

3986275

3986276

3986277

3986278

3986279

3986280

47534_at

79589

8169174

A_23_P148345

A_24_P340036

A_33_P3282880

GE87139

GO:0001818

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005770

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0006464

GO:0006511

GO:0008150

GO:0009056

GO:0012505

GO:0016020

GO:0016021

GO:0016567

GO:0016579

GO:0016740

GO:0031410

GO:0031647

GO:0043167

GO:0043226

GO:0046872

GO:0048471

GO:0061462

GO:0061630

GO:1904352

HMNXSV003044531

ILMN_1707807

ILMN_1775742

ILMN_1778338

PH_hs_0030973

TC0X000519.hg

g13375696_3p_at

Participates

as a component of

K48polyUb-RNF128:OTUB1 [cytosol] (Homo sapiens)

Other forms of this molecule

RNF128 [cytosol]

Inferred To

rnf128 [cytosol] (Xenopus tropicalis)

RNF128 [cytosol] (Canis familiaris)

RNF128 [cytosol] (Gallus gallus)

RNF128 [cytosol] (Sus scrofa)

rnf128a [cytosol] (Danio rerio)

gol [cytosol] (Drosophila melanogaster)

Rnf128 [cytosol] (Mus musculus)

Rnf128 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_078815.3, NP_919445.1

OpenTargets

ENSG00000133135

IntEnz

2.3.2.27

GeneCards

Q8TEB7

HPA

ENSG00000133135-RNF128

Ensembl

ENSG00000133135, ENST00000255499, ENST00000324342, ENSP00000316127, ENSP00000255499

PRO

Q8TEB7

Pharos - Targets

Q8TEB7

GlyGen

Q8TEB7

HMDB Protein

HMDBP09314

PDB

3ICU