EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5

Stable Identifier
R-HSA-6782685
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Proteins with major folding defects are extracted from futile folding cycles in the calnexin chaperone system and the ER Quality Control Compartment, and are translocated back to the cytosol for degradation. The ER degradation-enhancing alpha-mannosidase-like proteins 1 and 3 (EDEM1 and 3) can catalyse the sequential hydrolysis of (GlcNAc)2 (Man)8 to (GlcNAc)2 (Man)7-5. The products are recognised by quality control proteins and become targets for ER-associated degradation (ERAD) (Ninagawa et al. 2014, Hirao et al. 2006).

Literature References
PubMed ID Title Journal Year
16431915 EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

Hirao, K, Natsuka, Y, Tamura, T, Wada, I, Morito, D, Natsuka, S, Romero, P, Sleno, B, Tremblay, LO, Herscovics, A, Nagata, K, Hosokawa, N

J Biol Chem 2006
25092655 EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

Ninagawa, S, Okada, T, Sumitomo, Y, Kamiya, Y, Kato, K, Horimoto, S, Ishikawa, T, Takeda, S, Sakuma, T, Yamamoto, T, Mori, K

J. Cell Biol. 2014
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of EDEM1,3 [endoplasmic reticulum quality control compartment]
Physical Entity
Activity
Authored
Reviewed
Created