TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)

Stable Identifier
R-HSA-6782419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRDMT1 (DNMT2) transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-38 of tRNA(Asp) (Goll et al. 2006, Jurkowski et al. 2008, Jurkowski et al. 2012). TRDMT1 uses a similar mechanism to DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) (Jurkowski et al. 2008).

Literature References
PubMed ID Title Journal Year
18567810 Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism

Jurkowski, TP, Meusburger, M, Phalke, S, Helm, M, Nellen, W, Reuter, G, Jeltsch, A

RNA 2008
16424344 Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

Goll, MG, Kirpekar, F, Maggert, KA, Yoder, JA, Hsieh, CL, Zhang, X, Golic, KG, Jacobsen, SE, Bestor, TH

Science 2006
22591353 Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase

Jurkowski, TP, Shanmugam, R, Helm, M, Jeltsch, A

Biochemistry 2012
Participants
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Event Information
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Catalyst Activity

tRNA (cytosine-5-)-methyltransferase activity of TRDMT1 [nucleoplasm]

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