TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)

Stable Identifier
R-HSA-6782416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)
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TRMT1 (hTRM1) transfers two methyl groups from two molecules of S-adenosylmethionine to the 2 position of guanosine-26 of tRNA(Tyr), yielding 2-dimethylguanosine (Liu and Straby 2000). TRMT1 can dimethylate both spliced and unspliced tRNA (Liu and Straby 2000).
Literature References
PubMed ID Title Journal Year
10982862 The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene

Strâby, KB, Liu, J

Nucleic Acids Res. 2000
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanine(26)-N2)-dimethyltransferase activity of TRMT1 [nucleoplasm]

Physical Entity
TRMT1 [nucleoplasm] (Homo sapiens)
Activity
tRNA (guanine(26)-N2)-dimethyltransferase activity (GO:0160104)
Authored
May, B  (2015-06-07)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-08)
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