TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)

Stable Identifier
R-HSA-6782416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRMT1 (hTRM1) transfers two methyl groups from two molecules of S-adenosylmethionine to the 2 position of guanosine-26 of tRNA(Tyr), yielding 2-dimethylguanosine (Liu and Straby 2000). TRMT1 can dimethylate both spliced and unspliced tRNA (Liu and Straby 2000).

Literature References
PubMed ID Title Journal Year
10982862 The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene

Liu, J, Strâby, KB

Nucleic Acids Res. 2000
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Catalyst Activity
Title
tRNA (guanine-N2-)-methyltransferase activity of TRMT1 [nucleoplasm]
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