ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs

Stable Identifier
R-HSA-6782311
Type
Reaction [transition]
Species
Homo sapiens
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The ADAT2:ADAT3 heterodimer (hetADAT) deaminates adenosine-34 in 8 human tRNAs: tRNA(Ala-AGC), tRNA(Arg-ACG), tRNA(Ile-AAT), tRNA(leu-AAG), tRNA(Pro-AGG), tRNA(Ser-AGA), tRNA(Thr-AGT), tRNA(Val-AAC) (Torres et al. 2015). The deamination occurs in the nucleus on precursor tRNAs from which the 5' leaders and 3' trailers have not yet been cleaved. The corresponding homologues in Saccharomyces cerevisiae are Tad2p and Tad3p.

Literature References
PubMed ID Title Journal Year
25916855 Inosine modifications in human tRNAs are incorporated at the precursor tRNA level

Torres, AG, Piñeyro, D, Rodríguez-Escribà, M, Camacho, N, Reina, O, Saint-Léger, A, Filonava, L, Batlle, E, Ribas de Pouplana, L

Nucleic Acids Res. 2015
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Catalyst Activity
Title
tRNA-specific adenosine deaminase activity of ADAT2:ADAT3 [nucleoplasm]
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