DUS2:EPRS reduces uridine to dihydrouridine in tRNAs

Stable Identifier
R-HSA-6782296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DUS2 catalyzes the reduction of the 5,6 double bond in uridine residues in the D-loop of tRNAs, yielding 5,6-dihydrouridine (Kato et al. 2005). By inference with the homolog from Saccharomyces cerevisiae, Smm1p (Dus2p), NADH or NADPH is the reducing agent.

Literature References
PubMed ID Title Journal Year
15994936 A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis

Kato, T, Daigo, Y, Hayama, S, Ishikawa, N, Yamabuki, T, Ito, T, Miyamoto, M, Kondo, S, Nakamura, Y

Cancer Res. 2005
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
tRNA dihydrouridine synthase activity of DUS2:EPRS [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
Cite Us!