DUS2:EPRS reduces uridine to dihydrouridine in tRNAs

Stable Identifier
R-HSA-6782296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DUS2:EPRS reduces uridine to dihydrouridine in tRNAs
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DUS2 catalyzes the reduction of the 5,6 double bond in uridine residues in the D-loop of tRNAs, yielding 5,6-dihydrouridine (Kato et al. 2005). By inference with the homolog from Saccharomyces cerevisiae, Smm1p (Dus2p), NADH or NADPH is the reducing agent.

Literature References
PubMed ID Title Journal Year
15994936 A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis

Daigo, Y, Nakamura, Y, Ishikawa, N, Yamabuki, T, Hayama, S, Kondo, S, Miyamoto, M, Kato, T, Ito, T

Cancer Res. 2005
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA dihydrouridine synthase activity of DUS2:EPRS [cytosol]

Physical Entity
DUS2:EPRS [cytosol] (Homo sapiens)
Activity
tRNA dihydrouridine synthase activity (GO:0017150)
Inferred From
SMM1 (DUS2) reduces uridine-20 to dihydrouridine in tRNA(Leu) (Saccharomyces cerevisiae)
Authored
May, B  (2015-05-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-06)
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