CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs

Stable Identifier
R-HSA-6782264
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The CTU1:CTU2:URM1 complex transfers a thiol group from the thiolcarboxylated C-terminus of URM1 to uridine-34 residues of tRNAs, yielding 2-thiouridine-34 (Schlieker et al. 2008). The same reaction is catalyzed by TRMU (MTU1) in mitochondria.

Literature References
PubMed ID Title Journal Year
19017811 A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

Schlieker, CD, Van der Veen, AG, Damon, JR, Spooner, E, Ploegh, HL

Proc. Natl. Acad. Sci. U.S.A. 2008
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Catalyst Activity

sulfurtransferase activity of CTU1:CTU2:thio-URM1 [cytosol]

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