CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs

Stable Identifier
R-HSA-6782264
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs
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The CTU1:CTU2:URM1 complex transfers a thiol group from the thiolcarboxylated C-terminus of URM1 to uridine-34 residues of tRNAs, yielding 2-thiouridine-34 (Schlieker et al. 2008). The same reaction is catalyzed by TRMU (MTU1) in mitochondria.
Literature References
PubMed ID Title Journal Year
19017811 A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

Ploegh, HL, Spooner, E, Schlieker, CD, Damon, JR, Van der Veen, AG

Proc. Natl. Acad. Sci. U.S.A. 2008
Participants
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

sulfurtransferase activity of CTU1:CTU2:thio-URM1 [cytosol]

Physical Entity
CTU1:CTU2:thio-URM1 [cytosol] (Homo sapiens)
Activity
sulfurtransferase activity (GO:0016783)
Authored
May, B  (2015-05-30)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-06)
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