Ligation of newly synthesized repair patch to incised DNA in TC-NER

Stable Identifier
R-HSA-6782227
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Ligation of newly synthesized repair patch to incised DNA in TC-NER
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The nucleotide excision repair (NER) is completed when the newly synthesized fragment is ligated to the incised DNA strand, thus sealing the single stranded nick (SSB). Two DNA ligases, LIG1 and LIG3, can perform the ligation in transcription-coupled NER (TC-NER), as well as in global genome NER (GG-NER) (Arakawa et al. 2012, Paul-Konietzko et al. 2015).
Literature References
PubMed ID Title Journal Year
26131740 DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency

Arakawa, H, Paul-Konietzko, K, Iliakis, G, Thomale, J

Photochem Photobiol 2015
22127868 Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

Arakawa, H, Bednar, T, Wang, M, Mladenov, E, Bencsik-Theilen, AA, Iliakis, G, Paul, K

Nucleic Acids Res 2012
Participants
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Output
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as an event of
Catalyst Activity

DNA ligase activity of LIG1,LIG3:XRCC1 [nucleoplasm]

Physical Entity
LIG1,LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Activity
DNA ligase activity (GO:0003909)
Orthologous Events
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Dictyostelium discoideum)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Saccharomyces cerevisiae)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-06-16)
Hoeijmakers, JH  (2004-01-29)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-06-05)
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