Gap-filling DNA repair synthesis and ligation in TC-NER

Stable Identifier
Homo sapiens
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In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or LIG3, subsequently seal the single stranded nick by ligating the 3' end of the newly synthesized patch with the 5' end of incised DNA (Staresincic et al. 2009, Ogi et al. 2010, Arakawa et al. 2012, Paul-Konietzko et al. 2015).
Literature References
PubMed ID Title Journal Year
20227374 Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Limsirichaikul, S, Takenaka, K, Yamashita, S, Cloney, R, Lehmann, AR, Miki, Y, Mullenders, LH, Ogi, T, Overmeer, RM, Fousteri, M, Niimi, A, Jaspers, NG, Volker, M, Nakazawa, Y

Mol. Cell 2010
26131740 DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency

Arakawa, H, Paul-Konietzko, K, Iliakis, G, Thomale, J

Photochem Photobiol 2015
22127868 Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

Arakawa, H, Bednar, T, Wang, M, Mladenov, E, Bencsik-Theilen, AA, Iliakis, G, Paul, K

Nucleic Acids Res 2012
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Wijgers, N, Staresincic, L, Schärer, OD, Gourdin, AM, Fagbemi, AF, Enzlin, JH, Dunand-Sauthier, I, Clarkson, SG, Giglia-Mari, G, Vermeulen, W

EMBO J. 2009
Orthologous Events
Cross References
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