Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER

Stable Identifier
R-HSA-6782208
Type
Reaction
Species
Homo sapiens
Compartment
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In transcription-coupled nucleotide excision repair (TC-NER), as well as in global genome nucleotide excision repair (GG-NER), the DNA synthesis complex (NER post-incision complex) consisting of PCNA, RPA, RFC and polymerase delta (POLD) or epsilon (POLE) complexes performs DNA repair synthesis after the damaged DNA strand is incised 5' to the lesion by the endonuclease complex ERCC1:ERCC4 (ERCC1:XPF) and 3' to the lesion by the endonuclease XPG (ERCC5). Depending on damage-induced PCNA monoubiquitination, DNA polymerase kappa (POLK) may also be involved in gap-filling DNA synthesis during nucleotide excision repair (NER) (Balajee et al. 1998, Staresincic et al. 2009, Ogi et al. 2010, Overmeer et al. 2011).

Literature References
PubMed ID Title Journal Year
20227374 Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

Limsirichaikul, S, Takenaka, K, Yamashita, S, Cloney, R, Lehmann, AR, Miki, Y, Mullenders, LH, Ogi, T, Overmeer, RM, Fousteri, M, Niimi, A, Jaspers, NG, Volker, M, Nakazawa, Y

Mol. Cell 2010
9875289 Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair

Bohr, VA, Dianova, I, Balajee, AS, May, A

Mutat. Res. 1998
21282463 Replication protein A safeguards genome integrity by controlling NER incision events

Fousteri, M, Mullenders, LH, Volker, M, Moser, J, Kool, H, van Zeeland, AA, Overmeer, RM, Tomkinson, AE

J. Cell Biol. 2011
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Wijgers, N, Staresincic, L, Schärer, OD, Gourdin, AM, Fagbemi, AF, Enzlin, JH, Dunand-Sauthier, I, Clarkson, SG, Giglia-Mari, G, Vermeulen, W

EMBO J. 2009
Participants
Participates
Catalyst Activity

DNA-directed DNA polymerase activity of TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]

Orthologous Events
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