USP10 deubiquitinates SNX3, CFTR

Stable Identifier
R-HSA-6782106
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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USP10 deubiquitinates SNX3, CFTR
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USP10 deubiquitinates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC (Boulkroun et al. 2008). USP10 deubiquitinates CFTR in early endosomes thereby enhancing its endocytic recycling (Bomberger et al. 2009).
Literature References
PubMed ID Title Journal Year
19398555 The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells

Bomberger, JM, Barnaby, RL, Stanton, BA

J. Biol. Chem. 2009
18632802 Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3

Boulkroun, S, Ruffieux-Daidié, D, Vitagliano, JJ, Poirot, O, Charles, RP, Lagnaz, D, Firsov, D, Kellenberger, S, Staub, O

Am. J. Physiol. Renal Physiol. 2008
Participants
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Output
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as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP10:PolyUb-SNX3,PolyUb-CTFR [endosome membrane]

Physical Entity
USP10:PolyUb-SNX3,PolyUb-CTFR [endosome membrane] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP10 deubiquitinates SNX3, CFTR (Canis familiaris)
USP10 deubiquitinates SNX3, CFTR (Danio rerio)
USP10 deubiquitinates SNX3, CFTR (Gallus gallus)
USP10 deubiquitinates SNX3, CFTR (Mus musculus)
USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)
USP10 deubiquitinates SNX3, CFTR (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-04)
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