USP10 deubiquitinates SNX3, CFTR

Stable Identifier
R-HSA-6782106
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP10 deubiquitinates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC (Boulkroun et al. 2008). USP10 deubiquitinates CFTR in early endosomes thereby enhancing its endocytic recycling (Bomberger et al. 2009).

Literature References
PubMed ID Title Journal Year
18632802 Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3

Boulkroun, S, Ruffieux-DaidiƩ, D, Vitagliano, JJ, Poirot, O, Charles, RP, Lagnaz, D, Firsov, D, Kellenberger, S, Staub, O

Am. J. Physiol. Renal Physiol. 2008
19398555 The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells

Bomberger, JM, Barnaby, RL, Stanton, BA

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP10:PolyUb-SNX3,PolyUb-CTFR [endosome membrane]
Physical Entity
Activity
Orthologous Events
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