USP13 binds UFD1L:SKP2

Stable Identifier
R-HSA-6781922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP13 binds UFD1L:SKP2
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In the nucleus USP13 binds UFD1 which acts as a scaffold connecting USP13 to SKP2. USP13 mediates the deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD) by counteracting APC/C(Cdh1)-mediated SKP2 ubiquitination (Chen et al. 2011).
Literature References
PubMed ID Title Journal Year
21571647 Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control

Gutierrez, GJ, Ronai, ZA, Chen, M

Proc. Natl. Acad. Sci. U.S.A. 2011
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Orthologous Events
USP13 binds UFD1L:SKP2 (Bos taurus)
USP13 binds UFD1L:SKP2 (Drosophila melanogaster)
USP13 binds UFD1L:SKP2 (Gallus gallus)
USP13 binds UFD1L:SKP2 (Mus musculus)
USP13 binds UFD1L:SKP2 (Rattus norvegicus)
USP13 binds UFD1L:SKP2 (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-03)
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