In the nucleus USP13 binds UFD1 which acts as a scaffold connecting USP13 to SKP2. USP13 mediates the deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD) by counteracting APC/C(Cdh1)-mediated SKP2 ubiquitination (Chen et al. 2011).
Gutierrez, GJ, Ronai, ZA, Chen, M
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