Reactome | USP13 binds UFD1L:SKP2

USP13 binds UFD1L:SKP2

Stable Identifier

R-HSA-6781922

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the nucleus USP13 binds UFD1 which acts as a scaffold connecting USP13 to SKP2. USP13 mediates the deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD) by counteracting APC/C(Cdh1)-mediated SKP2 ubiquitination (Chen et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21571647	Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control Chen, M, Gutierrez, GJ, Ronai, ZA	Proc. Natl. Acad. Sci. U.S.A.	2011