USP13 binds UFD1L:SKP2

Stable Identifier
R-HSA-6781922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In the nucleus USP13 binds UFD1 which acts as a scaffold connecting USP13 to SKP2. USP13 mediates the deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD) by counteracting APC/C(Cdh1)-mediated SKP2 ubiquitination (Chen et al. 2011).

Literature References
PubMed ID Title Journal Year
21571647 Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control

Chen, M, Gutierrez, GJ, Ronai, ZA

Proc. Natl. Acad. Sci. U.S.A. 2011
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