USP11 deubiquitinates NFKBIA

Stable Identifier
R-HSA-6781897
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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USP11 deubiquitinates NFKBIA
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USP11 associates with and deubiquitinates NFKBIA (IkappaBalpha), downregulating TNFalpha-mediated NF-kappaB activation (Sun et al. 2010).

Literature References
PubMed ID Title Journal Year
19874889 USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha

Sun, W, Tan, X, Shi, Y, Xu, G, Mao, R, Gu, X, Fan, Y, Yu, Y, Burlingame, S, Zhang, H, Rednam, SP, Lu, X, Zhang, T, Fu, S, Cao, G, Qin, J, Yang, J

Cell. Signal. 2010
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Output
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as an event of
Catalyst Activity

thiol-dependent deubiquitinase activity of USP11:PolyUb-NFKBIA [cytosol]

Physical Entity
USP11:PolyUb-NFKBIA [cytosol] (Homo sapiens)
Activity
thiol-dependent deubiquitinase (GO:0004843)
Orthologous Events
USP11 deubiquitinates NFKBIA (Bos taurus)
USP11 deubiquitinates NFKBIA (Danio rerio)
USP11 deubiquitinates NFKBIA (Mus musculus)
USP11 deubiquitinates NFKBIA (Rattus norvegicus)
USP11 deubiquitinates NFKBIA (Sus scrofa)
Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-03)
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