USP11 deubiquitinates NFKBIA

Stable Identifier
R-HSA-6781897
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP11 associates with and deubiquitinates NFKBIA (IkappaBalpha), downregulating TNFalpha-mediated NF-kappaB activation (Sun et al. 2010).

Literature References
PubMed ID Title Journal Year
19874889 USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha

Sun, W, Tan, X, Shi, Y, Xu, G, Mao, R, Gu, X, Fan, Y, Yu, Y, Burlingame, S, Zhang, H, Rednam, SP, Lu, X, Zhang, T, Fu, S, Cao, G, Qin, J, Yang, J

Cell. Signal. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP11:PolyUb-NFKBIA [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created