Reactome | ERCC6 binds stalled RNA Pol II

ERCC6 binds stalled RNA Pol II

Stable Identifier

R-HSA-6781840

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cockayne syndrome protein B (ERCC6, also known as CSB) binds RNA polymerase II complex (RNA Pol II) stalled at a DNA damage site and is required for the subsequent recruitment of ERCC8 (CSA) (Kamiuchi et al. 2002, van der Weegen et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
32355176	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II van der Weegen, Y, Golan-Berman, H, Mevissen, TET, Apelt, K, González-Prieto, R, Goedhart, J, Heilbrun, EE, Vertegaal, ACO, van den Heuvel, D, Walter, JC, Adar, S, Luijsterburg, MS	Nat Commun	2020
11782547	Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair Kamiuchi, S, Saijo, M, Citterio, E, de Jager, M, Hoeijmakers, JH, Tanaka, K	Proc Natl Acad Sci U S A	2002