USP19 deubiquitinates RNF123

Stable Identifier
R-HSA-6781814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP19 is a deubiquitinating enzyme with a preference towards Lys-63-linked ubiquitin chains (Iphofer et al. 2012). It deubiquitinates RNF123, preventing its proteasomal degradation which in turn stimulates CDKN1B ubiquitin-dependent degradation and thereby cell proliferation (Lu et al. 2009).

Literature References
PubMed ID Title Journal Year
19015242 USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1

Lu, Y, Adegoke, OA, Nepveu, A, Nakayama, KI, Bedard, N, Cheng, D, Peng, J, Wing, SS

Mol. Cell. Biol. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP19:K63polyUb-RNF123 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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