USP19 is a deubiquitinating enzyme with a preference towards Lys-63-linked ubiquitin chains (Iphofer et al. 2012). It deubiquitinates RNF123, preventing its proteasomal degradation which in turn stimulates CDKN1B ubiquitin-dependent degradation and thereby cell proliferation (Lu et al. 2009).
Adegoke, OA, Peng, J, Bedard, N, Nepveu, A, Lu, Y, Nakayama, KI, Wing, SS, Cheng, D
cysteine-type deubiquitinase activity of USP19:K63polyUb-RNF123 [cytosol]
© 2023 Reactome
