Reactome | THBS3 [extracellular region]

THBS3 [extracellular region]

Stable Identifier

R-HSA-66522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Thrombospondin 3 precursor

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PDGF (Homo sapiens)
    - PDGF binds to extracellular matrix proteins (Homo sapiens)
      - Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Thrombospondin [extracellular region] (Homo sapiens)
        
        THBS3 [extracellular region] (Homo sapiens)
      - PDGF A and B chains:ECM complex [extracellular region] (Homo sapiens)
        
        Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Thrombospondin [extracellular region] (Homo sapiens)
        
        THBS3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49746 THBS3

Gene Names

THBS3, TSP3

Chain

signal peptide:1-22, chain:23-956

Reference Genes

BioGPS Gene:7059 THBS3

COSMIC (genes):THBS3 THBS3

CTD Gene:7059 THBS3

dbSNP Gene:7059 THBS3

ENSEMBL:ENSG00000169231 THBS3

HGNC:11787 THBS3

KEGG:hsa:7059 THBS3

Monarch:7059 THBS3

NCBI Gene:7059 THBS3

OMIM:188062 THBS3

UCSC:P49746 THBS3

Reference Transcript

Other Identifiers

11722043_a_at

11748351_a_at

16693996

209561_PM_at

209561_at

2437153

2437154

2437155

2437156

2437157

2437158

2437159

2437160

2437161

2437162

2437163

2437164

2437166

2437167

2437168

2437169

2437170

2437171

2437172

2437173

2437174

2437175

2437176

2437177

2437178

2437179

2437180

2437181

2437182

2437183

2437185

2437187

2437188

2437189

2437192

2437193

2437198

2437199

2437201

2437202

2437203

2437204

32670_at

7059

7920664

A_23_P201047

GE61266

GO:0003417

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005576

GO:0007155

GO:0007160

GO:0008201

GO:0030312

GO:0031012

GO:0043931

GO:0048471

GO:0048856

GO:0060346

GO:0062023

HMNXSV003043508

HMNXSV003053858

ILMN_1804663

L38969_at

PH_hs_0010130

TC01003305.hg

g886298_3p_at

Participates

as a member of

Thrombospondin [extracellular region] (Homo sapiens)

Inferred To

THBS3 [extracellular region] (Bos taurus)

THBS3 [extracellular region] (Canis familiaris)

THBS3 [extracellular region] (Sus scrofa)

Tsp [extracellular region] (Drosophila melanogaster)

thbs3a [extracellular region] (Danio rerio)

Thbs3 [extracellular region] (Mus musculus)

Thbs3 [extracellular region] (Rattus norvegicus)

thbs3 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_009043.1, NP_001239536.1, NP_001239537.1

ENSEMBL

ENST00000457183, ENSP00000357362, ENSP00000392207, ENST00000368378

OpenTargets

ENSG00000169231

HPA

ENSG00000169231-THBS3

PRO

P49746

Pharos - Targets

P49746

GlyGen

P49746

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.527	2
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.527	2
UniProt:Q8NB91 FANCB	2	FANCB [nucleoplasm] (R-HSA-419528) FANCB [cytosol] (R-HSA-420791)	0.527	2
UniProt:P07996 THBS1	5	THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518)	0.527	2

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