Reactome | THBS2 [extracellular region]

THBS2 [extracellular region]

Stable Identifier

R-HSA-66520

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Thrombospondin 2 precursor

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PDGF (Homo sapiens)
    - PDGF binds to extracellular matrix proteins (Homo sapiens)
      - Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Thrombospondin [extracellular region] (Homo sapiens)
        
        THBS2 [extracellular region] (Homo sapiens)
      - PDGF A and B chains:ECM complex [extracellular region] (Homo sapiens)
        
        Extracellular matrix ligands [extracellular region] (Homo sapiens)
        
        Thrombospondin [extracellular region] (Homo sapiens)
        
        THBS2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35442 THBS2

Gene Names

THBS2, TSP2

Chain

signal peptide:1-18, chain:19-1172

Reference Genes

BioGPS Gene:7058 THBS2

COSMIC (genes):THBS2 THBS2

CTD Gene:7058 THBS2

dbSNP Gene:7058 THBS2

ENSEMBL:ENSG00000186340 THBS2

ENSEMBL_homo_sapiens_GENE:ENSG00000186340.17 THBS2

HGNC:11786 THBS2

KEGG Gene (Homo sapiens):7058 THBS2

Monarch:7058 THBS2

NCBI Gene:7058 THBS2

OMIM:188061 THBS2

UCSC:P35442 THBS2

Reference Transcript

RefSeq:NM_003247.3 THBS2

Other Identifiers

11742711_at

11742712_a_at

11757941_s_at

17025844

203083_PM_at

203083_at

2985809

2985810

2985811

2985812

2985813

2985814

2985815

2985816

2985817

2985818

2985819

2985821

2985824

2985825

2985827

2985828

2985830

2985833

2985834

2985837

2985838

2985839

2985841

2985844

2985846

2985849

2985855

2985856

2985857

2985858

2985859

2985863

2985864

43353_at

658_at

659_g_at

7058

8130867

A_33_P3227375

A_33_P3365735

GE57615

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005576

GO:0005604

GO:0007155

GO:0008201

GO:0016525

GO:0030312

GO:0031012

GO:0031091

GO:0031410

GO:0034330

GO:0043226

GO:0048856

GO:0051965

GO:0062023

GO:0110165

HMNXSV003056773

ILMN_1678842

L12350_at

PH_hs_0028529

TC06002330.hg

g4507486_3p_at

Participates

as a member of

Thrombospondin [extracellular region] (Homo sapiens)

Other forms of this molecule

THBS2 [endoplasmic reticulum lumen]

glc-fuc-THBS2 [endoplasmic reticulum lumen]

O-fuc-THBS2 [endoplasmic reticulum lumen]

Inferred To

Homologues of THBS2 [extracellular region] (Drosophila melanogaster)

Tsp [extracellular region] (Drosophila melanogaster)

THBS2 [extracellular region] (Bos taurus)

THBS2 [extracellular region] (Canis familiaris)

THBS2 [extracellular region] (Gallus gallus)

THBS2 [extracellular region] (Sus scrofa)

Dmel\CG9297 [extracellular region] (Drosophila melanogaster)

thbs2 [extracellular region] (Xenopus tropicalis)

Thbs2 [extracellular region] (Mus musculus)

Thbs2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_003238.2

OpenTargets

ENSG00000186340

GeneCards

P35442

HPA

ENSG00000186340-THBS2

Ensembl

ENST00000676498, ENSP00000504820, ENST00000366787, ENSG00000186340, ENSP00000503020, ENSP00000482784, ENSP00000355751, ENST00000676760, ENST00000617924

PRO

P35442

Pharos - Targets

P35442

PDB

1YO8, 2RHP