Reactome | TNFRSF1A(22-455) [plasma membrane]

TNFRSF1A(22-455) [plasma membrane]

Stable Identifier

R-HSA-66344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TNF-RI, Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (p55) (CD120a) (Contains: Tumor necrosis factor binding protein 1 (TBPI)), Tumor necrosis factor receptor superfamily member 1A precursor, p60, TNF-R1, p55, CD120a, Tumor necrosis factor binding protein 1, TBPI

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External Reference Information

External Reference

UniProt:P19438 TNFRSF1A

Gene Names

TNFRSF1A, TNFAR, TNFR1

Chain

signal peptide:1-29, chain:30-455, chain:41-201

Reference Genes

BioGPS Gene:7132 TNFRSF1A

COSMIC (genes):TNFRSF1A TNFRSF1A

CTD Gene:7132 TNFRSF1A

dbSNP Gene:7132 TNFRSF1A

ENSEMBL:ENSG00000067182 TNFRSF1A

HGNC:11916 TNFRSF1A

KEGG Gene (Homo sapiens):7132 TNFRSF1A

Monarch:7132 TNFRSF1A

NCBI Gene:7132 TNFRSF1A

OMIM:191190 TNFRSF1A

UCSC:P19438 TNFRSF1A

Reference Transcript

Other Identifiers

0004060112

10309

11739346_s_at

11752814_s_at

11754297_s_at

11760872_at

1563_s_at

16760329

1EXT

1FT4

1ICH

1NCF

1TNR

207643_s_at

3441850

3441851

3441852

3441853

3441854

3441855

3441856

3441857

3441858

3441859

3441860

3441861

3441863

3441864

3441865

3441866

3441867

3441868

3441869

3441871

3441878

3441879

4102

7132

7960518

A_23_P139722

AAA03210

AAA36753

AAA36754

AAA36756

AAA61201

AAH10140

AAM77802

AC006057

ACH57451

AK056611

AK291088

AK298729

AK304517

AK315509

AY131997

BAF83777

BAG37891

BAG51763

BAG60879

BAG65321

BC010140

CAA39021

CAB010309

CCDS8542

CH471116

EAW88805

EAW88806

ENSG00000067182

ENSP00000162749

ENSP00000380389

ENST00000162749

ENST00000162749.6

ENST00000366159

ENST00000366159.8

EntrezGene:7132

EntrezGene:TNFRSF1A

EU927389

F5GWJ4

F5H061

F5H4T5

F5H6V7

F5H6Z2

F5H7N1

F5H8A6

g4507574_3p_a_at

GE59806

GO:0000139

GO:0002947

GO:0003176

GO:0003177

GO:0003332

GO:0003674

GO:0005031

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005794

GO:0005886

GO:0005887

GO:0006464

GO:0006629

GO:0006693

GO:0006810

GO:0006915

GO:0006950

GO:0006952

GO:0006954

GO:0007165

GO:0007166

GO:0007249

GO:0008150

GO:0008219

GO:0008625

GO:0008630

GO:0009058

GO:0009986

GO:0010614

GO:0010803

GO:0016020

GO:0016021

GO:0016032

GO:0019221

GO:0022607

GO:0030154

GO:0030198

GO:0032991

GO:0033209

GO:0034641

GO:0042531

GO:0042742

GO:0043120

GO:0043123

GO:0043226

GO:0043235

GO:0044281

GO:0044403

GO:0045121

GO:0045944

GO:0048856

GO:0050728

GO:0050729

GO:0065003

GO:0071260

GO:0071550

GO:0072659

GO:1902339

GO:1903140

GO:2000304

HGNC:11916

HPA004102

ILMN_1685005

IPR000488

IPR001368

IPR011029

IPR020419

IPR033993

IPR033994

LRG_193

LRG_193t1

M33294

M58286

M58286_s_at

M60275

M63121

M75864

M75865

M75866

MIM:142680

MIM:191190

MIM:614810

NM_001065

NP_001056

NR_144351

PF00020

PF00531

PH_hs_0027516

PR01918

SM00005

SM00208

TC12001135.hg

TNFRSF1A

TNFRSF1A-201

TNFRSF1A-202

UPI000002CE11

UPI00017FB1A0

X55313

Participant Of

hasComponent

Other forms of this molecule

TNFRSF1A(41-201) [extracellular region]

TNFRSF1A [plasma membrane]

Inferred To

TNFRSF1A [plasma membrane] (Canis familiaris)

Tnfrsf1a [plasma membrane] (Mus musculus)

Tnfrsf1a [plasma membrane] (Rattus norvegicus)

TNFRSF1A(22-455) [plasma membrane] (Xenopus tropicalis)

tnfrsf1a [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001333021.1, NP_001056.1, NP_001333020.1

ZINC - World Drugs

TNR1A_HUMAN

OpenTargets

ENSG00000067182

ZINC - Substances

TNR1A_HUMAN

ZINC - Biogenic

TNR1A_HUMAN

ZINC target

P19438

PRO

P19438

PDB

1EXT, 1ICH, 1NCF, 1FT4, 1TNR

GeneCards

P19438

HPA

ENSG00000067182-TNFRSF1A

Ensembl

ENSG00000067182, ENST00000162749, ENST00000366159, ENSP00000162749, ENSP00000380389

ZINC - Predictions - Purchasable

TNR1A_HUMAN

Orphanet

15636

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.954	15
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.937	15
UniProt:Q13546 RIPK1	9	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) p-S-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1 [cytosol] (R-HSA-168651)	0.839	6
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.773	5
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.69	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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