Reactome | TNFRSF1A(22-455) [plasma membrane]

TNFRSF1A(22-455) [plasma membrane]

Stable Identifier

R-HSA-66344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TNF-RI, Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (p55) (CD120a) (Contains: Tumor necrosis factor binding protein 1 (TBPI)), Tumor necrosis factor receptor superfamily member 1A precursor, p60, TNF-R1, p55, CD120a, Tumor necrosis factor binding protein 1, TBPI

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External Reference Information

External Reference

UniProt:P19438 TNFRSF1A

Gene Names

TNFRSF1A, TNFAR, TNFR1

Chain

signal peptide:1-29, chain:30-455, chain:41-201

Reference Genes

BioGPS Gene:7132 TNFRSF1A

COSMIC (genes):TNFRSF1A TNFRSF1A

CTD Gene:7132 TNFRSF1A

dbSNP Gene:7132 TNFRSF1A

ENSEMBL:ENSG00000067182 TNFRSF1A

HGNC:11916 TNFRSF1A

KEGG Gene (Homo sapiens):7132 TNFRSF1A

Monarch:7132 TNFRSF1A

NCBI Gene:7132 TNFRSF1A

OMIM:191190 TNFRSF1A

UCSC:P19438 TNFRSF1A

Reference Transcript

Other Identifiers

0004060112

11739346_s_at

11752814_s_at

11754297_s_at

11760872_at

1563_s_at

16760329

207643_s_at

3441850

3441851

3441852

3441853

3441854

3441855

3441856

3441857

3441858

3441859

3441860

3441861

3441863

3441864

3441865

3441866

3441867

3441868

3441869

3441871

3441878

3441879

7132

7960518

A_23_P139722

GE59806

GO:0000139

GO:0002947

GO:0003176

GO:0003177

GO:0003332

GO:0003674

GO:0005031

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005739

GO:0005794

GO:0005886

GO:0005887

GO:0006464

GO:0006629

GO:0006693

GO:0006810

GO:0006915

GO:0006950

GO:0006952

GO:0006954

GO:0007165

GO:0007166

GO:0007249

GO:0008150

GO:0008219

GO:0008625

GO:0008630

GO:0009058

GO:0009986

GO:0010614

GO:0010803

GO:0016020

GO:0016021

GO:0016032

GO:0019221

GO:0022607

GO:0030154

GO:0030198

GO:0032991

GO:0033209

GO:0034641

GO:0042531

GO:0042742

GO:0042802

GO:0043120

GO:0043123

GO:0043226

GO:0043235

GO:0044281

GO:0044403

GO:0045121

GO:0045944

GO:0048856

GO:0050728

GO:0050729

GO:0065003

GO:0071260

GO:0071550

GO:0072659

GO:1902339

GO:1903140

GO:2000304

HMNXSV003033824

ILMN_1685005

M58286_s_at

PH_hs_0027516

TC12001135.hg

g4507574_3p_a_at

Participates

as a component of

Other forms of this molecule

TNFRSF1A(41-201) [extracellular region]

TNFRSF1A [plasma membrane]

Inferred To

TNFRSF1A [plasma membrane] (Canis familiaris)

Tnfrsf1a [plasma membrane] (Mus musculus)

Tnfrsf1a [plasma membrane] (Rattus norvegicus)

tnfrsf1a [plasma membrane] (Danio rerio)

tnfrsf1a [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001333020.1, NP_001056.1, NP_001333021.1

OpenTargets

ENSG00000067182

GeneCards

P19438

ZINC - Substances

TNR1A_HUMAN

HPA

ENSG00000067182-TNFRSF1A

ZINC - Biogenic

TNR1A_HUMAN

Ensembl

ENSP00000380389, ENST00000162749, ENSG00000067182, ENST00000366159, ENSP00000162749

ZINC target

P19438

PRO

P19438

ZINC - Predictions - Purchasable

TNR1A_HUMAN

Orphanet

15636

PDB

1NCF, 1TNR, 1EXT, 7K7A, 1FT4, 1ICH

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.954	15
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.934	15
UniProt:Q13546 RIPK1	14	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.839	6
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.745	5
UniProt:Q13490 BIRC2	5	BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.69	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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