Reactome | POLR2K [nucleoplasm]

POLR2K [nucleoplasm]

Stable Identifier

R-HSA-63537

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA-directed RNA polymerases I, II, and III 7.0 kDa polypeptide , ABC10-alpha, RPB7.0, RPB10alpha, RPABC4

Locations in the PathwayBrowser for interactor UniProt:O95602 POLR1A

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External Reference Information

External Reference

UniProt:P53803 POLR2K

Gene Names

POLR2K

Chain

chain:1-58

Reference Genes

BioGPS Gene:5440 POLR2K

COSMIC (genes):POLR2K POLR2K

CTD Gene:5440 POLR2K

dbSNP Gene:5440 POLR2K

ENSEMBL:ENSG00000147669 POLR2K

ENSEMBL_homo_sapiens_GENE:ENSG00000147669.11 POLR2K

HGNC:9198 POLR2K

KEGG Gene (Homo sapiens):5440 POLR2K

Monarch:5440 POLR2K

NCBI Gene:5440 POLR2K

OMIM:606033 POLR2K

UCSC:P53803 POLR2K

Reference Transcript

RefSeq:NM_005034.3 POLR2K

Other Identifiers

11717668_x_at

11745003_a_at

17071404

202634_PM_at

202634_at

202635_PM_s_at

202635_s_at

3109192

3109194

3109196

3109199

3109200

39766_r_at

5440

8147654

A_23_P157452

GE80032

GE85842

GO:0000428

GO:0001054

GO:0001055

GO:0001056

GO:0003677

GO:0003824

GO:0003899

GO:0005515

GO:0005634

GO:0005654

GO:0005665

GO:0005666

GO:0005730

GO:0005736

GO:0005829

GO:0006351

GO:0006355

GO:0006356

GO:0006360

GO:0006366

GO:0006383

GO:0008270

GO:0016740

GO:0043226

GO:0046872

GO:0140098

HMNXSV003025275

Hs.150675.0.S2_3p_x_at

ILMN_1659026

PH_hs_0029822

TC08000612.hg

Z47727_at

g4826923_3p_a_at

Participates

as a component of

as an input of

Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)

Other forms of this molecule

POLR2K [cytosol]

Inferred To

Ghost homologue of POLR2K [nucleoplasm] (Danio rerio)

Ghost homologue of POLR2K [nucleoplasm] (Rattus norvegicus)

rpb-12 [nucleoplasm] (Caenorhabditis elegans)

polr2k [nucleoplasm] (Xenopus tropicalis)

POLR2K [nucleoplasm] (Bos taurus)

POLR2K [nucleoplasm] (Canis familiaris)

POLR2K [nucleoplasm] (Dictyostelium discoideum)

POLR2K [nucleoplasm] (Gallus gallus)

POLR2K [nucleoplasm] (Mus musculus)

POLR2K [nucleoplasm] (Plasmodium falciparum)

POLR2K [nucleoplasm] (Saccharomyces cerevisiae)

POLR2K [nucleoplasm] (Schizosaccharomyces pombe)

POLR2K [nucleoplasm] (Sus scrofa)

Polr2K [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_005025.1

OpenTargets

ENSG00000147669

HPA

ENSG00000147669-POLR2K

GeneCards

P53803

Ensembl

ENST00000353107, ENSP00000342889, ENSG00000147669

PRO

P53803

Pharos - Targets

P53803

HMDB Protein

HMDBP11914

PDB

8IUH, 7VBB, 6DRD, 7D58, 7FJI, 7VBC, 5IY7, 7A6H, 7AE1, 7D59, 6O9L, 5IYD, 5IY6, 7FJJ, 7AST, 8IUE, 7VBA, 7DU2, 5IY9, 5IY8, 5IYB, 7OBA, 7LBM, 7AEA, 5IYA, 8ITY, 7OBB, 7DN3, 5IYC, 7AE3, 8A43, 6XRE, 7OB9

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.772	7
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.556	3
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.527	4
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.527	2
UniProt:Q9NVU0 POLR3E	2	POLR3E [nucleoplasm] (R-HSA-83706) POLR3E [cytosol] (R-HSA-1964451)	0.527	3
UniProt:Q96P16 RPRD1A	1	RPRD1A [nucleoplasm] (R-HSA-6814899)	0.527	2
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.527	3

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