Reactome | POLR1C [nucleoplasm]

POLR1C [nucleoplasm]

Stable Identifier

R-HSA-63498

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HsRPAC1, DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I and III 40 kDa polypeptide , RPA40, RPA39

Locations in the PathwayBrowser for interactor UniProt:O95602 POLR1A

Expand all

External Reference Information

External Reference

UniProt:O15160 POLR1C

Gene Names

POLR1C, POLR1E

Chain

initiator methionine:, chain:2-346

Reference Genes

BioGPS Gene:9533 POLR1C

COSMIC (genes):POLR1C POLR1C

CTD Gene:9533 POLR1C

dbSNP Gene:9533 POLR1C

ENSEMBL:ENSG00000171453 POLR1C

ENSEMBL_homo_sapiens_GENE:ENSG00000171453.20 POLR1C

HGNC:20194 POLR1C

KEGG Gene (Homo sapiens):9533 POLR1C

Monarch:9533 POLR1C

NCBI Gene:9533 POLR1C

OMIM:610060 POLR1C

UCSC:O15160 POLR1C

Reference Transcript

Other Identifiers

11719195_a_at

11740797_x_at

17009032

207515_PM_s_at

207515_s_at

209317_PM_at

209317_at

2908053

2908054

2908055

2908056

2908059

2908061

2908062

2908064

2908065

2908067

2908069

2908070

2908072

2908073

2908074

2908076

2908099

36460_at

8119842

9533

A_14_P119687

A_33_P3339103

GO:0000428

GO:0001054

GO:0001056

GO:0001650

GO:0003677

GO:0003824

GO:0003899

GO:0005515

GO:0005634

GO:0005654

GO:0005666

GO:0005730

GO:0005736

GO:0005737

GO:0005829

GO:0006351

GO:0006360

GO:0006383

GO:0016740

GO:0043226

GO:0046983

GO:0140098

HMNXSV003040440

ILMN_1746686

ILMN_1767219

PH_hs_0000558

g2266928_3p_at

g4759045_3p_a_at

Participates

as a component of

as an input of

Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)

Other forms of this molecule

POLR1C [cytosol]

Inferred To

polr1c [nucleoplasm] (Dictyostelium discoideum)

Polr1c [nucleoplasm] (Mus musculus)

POLR1C [nucleoplasm] (Bos taurus)

POLR1C [nucleoplasm] (Canis familiaris)

POLR1C [nucleoplasm] (Gallus gallus)

POLR1C [nucleoplasm] (Plasmodium falciparum)

POLR1C [nucleoplasm] (Rattus norvegicus)

POLR1C [nucleoplasm] (Sus scrofa)

rpac-40 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of POLR1C [nucleoplasm] (Xenopus tropicalis)

rpc40 [nucleoplasm] (Schizosaccharomyces pombe)

Polr1C [nucleoplasm] (Drosophila melanogaster)

RPC40 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001305805.1, NP_976035.1

OpenTargets

ENSG00000171453

HPA

ENSG00000171453-POLR1C

GeneCards

O15160

Ensembl

ENST00000607635, ENST00000304004, ENSP00000496683, ENSP00000496044, ENSP00000307212, ENSG00000171453, ENST00000642195

PRO

O15160

Pharos - Targets

O15160

Orphanet

19587

HMDB Protein

HMDBP11916

PDB

7D59, 7AEA, 7VBC, 8ITY, 7DU2, 7DN3, 7AE1, 7OBA, 7A6H, 7FJI, 7OBB, 7AST, 7AE3, 7VBA, 8A43, 7FJJ, 7D58, 7OB9, 8IUE, 8IUH, 7VBB

Interactors (132)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DPB6 RPAC2			0.918	19
UniProt:P15531 NME1	1	NME1 [cytosol] (R-HSA-60022)	0.87	11
UniProt:Q9UKT9 IKZF3			0.841	9
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.831	12
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.781	9
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.775	7
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.725	5
UniProt:Q9UFD9 RIM3A			0.718	6
UniProt:Q9Y3Q8 T22D4			0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.718	6
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.718	6
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.718	6
UniProt:Q8NA61-2 CBY2			0.696	5
UniProt:Q13064 MKRN3			0.696	5
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.696	5
UniProt:Q9GZS1 POLR1E	1	POLR1E [nucleoplasm] (R-HSA-5419294)	0.669	5
UniProt:Q9NVU0 POLR3E	2	POLR3E [nucleoplasm] (R-HSA-83706) POLR3E [cytosol] (R-HSA-1964451)	0.643	5
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.643	6
UniProt:Q9HAV7 GRPEL1	1	GRPEL1 [mitochondrial inner membrane] (R-HSA-1252062)	0.601	4
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.601	4
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [extracellular region] (R-HSA-6806289) CRACR2A [specific granule lumen] (R-HSA-6799553)	0.556	3
UniProt:P19237 TNNI1	1	TNNI1 [cytosol] (R-HSA-390539)	0.556	3
UniProt:Q5VWN6-2 TASOR2			0.556	3
UniProt:Q8IYA8 IHO1			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q8WZ19 KCTD13	1	KCTD13 [cytosol] (R-HSA-9696533)	0.556	3
UniProt:Q9H1A7 RPB1C			0.556	3
UniProt:Q9BWF2 TRAIP	1	TRAIP [cytosol] (R-HSA-8851652)	0.556	3
UniProt:Q9UHP6 RSP14			0.556	3
UniProt:Q9NU63-3 ZFP57			0.556	3
UniProt:Q96LM5 SMIP2			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:Q9Y3D9 MRPS23	1	MRPS23 [mitochondrial inner membrane] (R-HSA-5368249)	0.556	3
UniProt:Q9H4Y5 GSTO2	1	GSTO2 [cytosol] (R-HSA-176066)	0.556	3
UniProt:Q9Y5P6 GMPPB	1	GMPPB [cytosol] (R-HSA-532525)	0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q5RL73 RBM48			0.556	3
UniProt:Q7Z353 HDX			0.556	3
UniProt:P59991 KRTAP12-2	1	KRTAP12-2 [cytosol] (R-HSA-6810271)	0.556	3
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.556	3
UniProt:Q5T686 AVPI1			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:O95561 CA105			0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:P17482 HXB9			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q01546 KRT76	1	KRT76 [cytosol] (R-HSA-6809633)	0.556	5
UniProt:O96000 NDUFB10	1	NDUFB10 [mitochondrial inner membrane] (R-HSA-60194)	0.556	3
UniProt:Q9NZ72 STMN3			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:Q5T3J3 LRIF1			0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:B2RXF5 ZBT42			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q9Y2P0 ZN835			0.556	3
UniProt:Q8WXE1 ATRIP	1	ATRIP [nucleoplasm] (R-HSA-176231)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:P07954 FH	1	FH [mitochondrial matrix] (R-HSA-70980)	0.556	3
UniProt:Q8IXW7 Q8IXW7			0.556	3
UniProt:P46934-3 NEDD4			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q0VAL7 Q0VAL7			0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:Q8WUT1 Q8WUT1			0.556	3
UniProt:P0C7X2 ZNF688	1	ZNF688 [nucleoplasm] (R-HSA-2248884)	0.556	3
UniProt:Q6PI77 GASP3			0.556	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:A8MW99 MEI4			0.556	3
UniProt:Q9BTD3 TM121			0.556	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.556	5
UniProt:Q8IVP9 ZNF547	1	ZNF547 [nucleoplasm] (R-HSA-1973874)	0.556	3
UniProt:Q6PJQ5 FOXR2			0.556	3
UniProt:Q86TJ5 ZNF554	1	ZNF554 [nucleoplasm] (R-HSA-1973883)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q9H0A9-2 SPATC1L			0.556	3
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.556	5
UniProt:Q9UFW8 CGBP1			0.556	3
UniProt:P35452-2 P354522			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:O75909-2 CCNK			0.556	3
UniProt:Q9H9P5-5 UNKL			0.556	3
UniProt:Q9NQY0 BIN3			0.556	3
UniProt:Q969Q6 P2R3C			0.556	5
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	5
UniProt:O43609 SPRY1	3	p-Y53-SPRY1 [cytosol] (R-HSA-182933) SPRY1 [plasma membrane] (R-HSA-182944) SPRY1 [cytosol] (R-HSA-182908)	0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q6ZNM6 SMI10			0.556	3
UniProt:A0A0A0MR80 A0A0A0MR80			0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q9H6T3 RPAP3			0.527	2
UniProt:O75575 CRCP	2	CRCP [nucleoplasm] (R-HSA-5420844) CRCP [cytosol] (R-HSA-5420849)	0.527	3
UniProt:Q9HCN4 GPN1			0.527	2
UniProt:Q9NW08 POLR3B	2	POLR3B [cytosol] (R-HSA-1964435) POLR3B [nucleoplasm] (R-HSA-83702)	0.527	4
UniProt:Q9UHW5 GPN3			0.527	3
UniProt:P52434 POLR2H	2	POLR2H [nucleoplasm] (R-HSA-63523) POLR2H [cytosol] (R-HSA-1964450)	0.527	3
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.527	2
UniProt:Q9Y2Y1 POLR3K	2	POLR3K [nucleoplasm] (R-HSA-1964461) POLR3K [cytosol] (R-HSA-1964455)	0.527	3
UniProt:Q9BUI4 POLR3C	2	POLR3C [cytosol] (R-HSA-1964448) POLR3C [nucleoplasm] (R-HSA-1964430)	0.527	4
UniProt:Q9BT43 POLR3GL	2	POLR3GL [nucleoplasm] (R-HSA-1964458) POLR3GL [cytosol] (R-HSA-1964463)	0.527	4
UniProt:P05423 POLR3D	2	POLR3D [nucleoplasm] (R-HSA-83704) POLR3D [cytosol] (R-HSA-1964429)	0.527	4
UniProt:Q9Y535 POLR3H	2	POLR3H [nucleoplasm] (R-HSA-83710) POLR3H [cytosol] (R-HSA-1964440)	0.527	5
UniProt:O14802 POLR3A	2	POLR3A [cytosol] (R-HSA-1964433) POLR3A [nucleoplasm] (R-HSA-83700)	0.527	4
UniProt:O15318 POLR3G	2	POLR3G [nucleoplasm] (R-HSA-1964459) POLR3G [cytosol] (R-HSA-1964446)	0.527	4
UniProt:Q9H1D9 POLR3F	2	POLR3F [cytosol] (R-HSA-1964434) POLR3F [nucleoplasm] (R-HSA-83708)	0.527	4
UniProt:Q3B726 POLR1F	1	TWISTNB [nucleoplasm] (R-HSA-5419290)	0.527	2
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.527	3
UniProt:O15446 POLR1G	1	CD3EAP [nucleoplasm] (R-HSA-5419289)	0.527	3
UniProt:Q9H9Y6 POLR1B	1	POLR1B [nucleoplasm] (R-HSA-63496)	0.527	4
UniProt:Q8N448 LNX2			0.488	2

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