Reactome | POLR1B [nucleoplasm]

POLR1B [nucleoplasm]

Stable Identifier

R-HSA-63496

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA-directed RNA polymerase I 135 kDa polypeptide , RNA polymerase I subunit 2, RPA135

Locations in the PathwayBrowser for interactor UniProt:O95602 POLR1A

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External Reference Information

External Reference

UniProt:Q9H9Y6 POLR1B

Gene Names

POLR1B

Chain

chain:1-1135

Reference Genes

BioGPS Gene:84172 POLR1B

COSMIC (genes):POLR1B POLR1B

CTD Gene:84172 POLR1B

dbSNP Gene:84172 POLR1B

ENSEMBL:ENSG00000125630 POLR1B

ENSEMBL_homo_sapiens_GENE:ENSG00000125630.16 POLR1B

HGNC:20454 POLR1B

KEGG Gene (Homo sapiens):84172 POLR1B

Monarch:84172 POLR1B

NCBI Gene:84172 POLR1B

OMIM:602000 POLR1B

UCSC:Q9H9Y6 POLR1B

Reference Transcript

Other Identifiers

11739337_s_at

11741721_x_at

11746302_a_at

11748605_a_at

11748606_x_at

11755321_x_at

1557331_3p_at

1557331_PM_at

1557331_at

16884473

220113_PM_x_at

220113_x_at

223403_PM_s_at

223403_s_at

233341_PM_s_at

233341_s_at

2500837

2500839

2500840

2500841

2500843

2500844

2500845

2500847

2500849

2500850

2500851

2500852

2500853

2500854

2500856

2500858

2500860

2500861

2500862

2500863

2500864

2500865

2500866

2500867

2500868

2500869

2500871

62960_at

8044473

83482_r_at

84172

A_23_P209987

GE55872

GE872363

GO:0000428

GO:0001054

GO:0001650

GO:0003677

GO:0003824

GO:0003899

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005736

GO:0005829

GO:0006351

GO:0006360

GO:0007566

GO:0008270

GO:0009303

GO:0014029

GO:0016740

GO:0016779

GO:0017126

GO:0022414

GO:0030154

GO:0032549

GO:0034062

GO:0043226

GO:0046872

GO:0048856

GO:0071667

GO:0140098

HMNXSV003047288

Hs.86337.2.S1_3p_a_at

Hs2.212849.1.S1_3p_x_at

ILMN_1794632

ILMN_2067101

PH_hs_0004859

TC02000707.hg

g13436127_3p_a_at

Participates

as an input of

Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)

as a component of

RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)

Inferred To

RPA135 [nucleoplasm] (Saccharomyces cerevisiae)

rpoa-2 [nucleoplasm] (Caenorhabditis elegans)

polr1b [nucleoplasm] (Dictyostelium discoideum)

polr1b [nucleoplasm] (Xenopus tropicalis)

POLR1B [nucleoplasm] (Bos taurus)

POLR1B [nucleoplasm] (Canis familiaris)

POLR1B [nucleoplasm] (Gallus gallus)

POLR1B [nucleoplasm] (Mus musculus)

POLR1B [nucleoplasm] (Plasmodium falciparum)

POLR1B [nucleoplasm] (Rattus norvegicus)

POLR1B [nucleoplasm] (Sus scrofa)

Polr1B [nucleoplasm] (Drosophila melanogaster)

rpa2 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001269708.1, NP_001269703.1, NP_001269706.1, NP_061887.2, NP_001131076.1, NP_001269701.1, NP_001269705.1

OpenTargets

ENSG00000125630

HPA

ENSG00000125630-POLR1B

GeneCards

Q9H9Y6

Ensembl

ENST00000541869, ENSP00000437914, ENST00000263331, ENST00000409894, ENSP00000263331, ENSP00000444136, ENSG00000125630, ENST00000537335, ENSP00000405358, ENST00000417433, ENSP00000387143

PRO

Q9H9Y6

Pharos - Targets

Q9H9Y6

Orphanet

29805

PDB

7VBC, 7OB9, 7OBA, 7VBA, 7OBB, 7VBB, 8A43

HMDB Protein

HMDBP00743

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.744	4
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.643	4
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.643	5
UniProt:Q3B726 POLR1F	1	TWISTNB [nucleoplasm] (R-HSA-5419290)	0.527	3
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.527	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.527	4
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.488	2

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