Reactome | CALM1:4xCa2+ [nucleoplasm]

CALM1:4xCa2+ [nucleoplasm]

Stable Identifier

R-HSA-629658

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Active Calmodulin, Ca(4)CaM

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Disorders of Developmental Biology (Homo sapiens)
  - Disorders of Nervous System Development (Homo sapiens)
    - Pervasive developmental disorders (Homo sapiens)
      - Loss of function of MECP2 in Rett syndrome (Homo sapiens)
        
        Loss of phosphorylation of MECP2 at T308 (Homo sapiens)
        
        Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308 (Homo sapiens)
        
        Active PRKACA,CaMK IV [nucleoplasm] (Homo sapiens)
        
        CAMK4:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
        
        Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
        
        NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
        
        CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated Ca+2 mobilization (Homo sapiens)
      - Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
        
        NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Homo sapiens)
        
        CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
7526403	Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation. Yau, KW, Illing, M, Molday, LL, Molday, RS, Chen, TY, Hsu, YT	Proc Natl Acad Sci U S A	1994

Participants

components

Participates

as a component of

as an input of

as an output of

Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)

Inferred To

CALM1:4xCa2+ [nucleoplasm] (Bos taurus)

CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)

CALM1:4xCa2+ [nucleoplasm] (Canis familiaris)

CALM1:4xCa2+ [nucleoplasm] (Dictyostelium discoideum)

CALM1:4xCa2+ [nucleoplasm] (Drosophila melanogaster)

CALM1:4xCa2+ [nucleoplasm] (Gallus gallus)

CALM1:4xCa2+ [nucleoplasm] (Plasmodium falciparum)

CALM1:4xCa2+ [nucleoplasm] (Rattus norvegicus)

CALM1:4xCa2+ [nucleoplasm] (Schizosaccharomyces pombe)

CALM1:4xCa2+ [nucleoplasm] (Sus scrofa)

CALM1:4xCa2+ [nucleoplasm] (Xenopus tropicalis)

Calmodulin:Calcium [nucleoplasm] (Mus musculus)

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