Reactome | RAD52 [nucleoplasm]

RAD52 [nucleoplasm]

Stable Identifier

R-HSA-62639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein RAD52 homolog

Locations in the PathwayBrowser for interactor UniProt:Q14191%20WRN

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SUMOylation of RAD52 with SUMO1 (Homo sapiens)
        
        RAD52 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43351 RAD52

Gene Names

RAD52

Chain

chain:1-418

Reference Genes

BioGPS Gene:5893 RAD52

COSMIC (genes):RAD52 RAD52

CTD Gene:5893 RAD52

dbSNP Gene:5893 RAD52

ENSEMBL:ENSG00000002016 RAD52

ENSEMBL_homo_sapiens_GENE:ENSG00000002016.18 RAD52

HGNC:9824 RAD52

KEGG Gene (Homo sapiens):5893 RAD52

Monarch:5893 RAD52

NCBI Gene:5893 RAD52

OMIM:600392 RAD52

UCSC:P43351 RAD52

Reference Transcript

Other Identifiers

1043_s_at

11731758_at

11731759_s_at

11731760_a_at

11731761_x_at

11746884_a_at

11746885_s_at

11746886_x_at

11748832_a_at

11749968_a_at

11752970_a_at

11753544_a_at

11753545_x_at

1899_s_at

205647_PM_at

205647_at

210630_PM_s_at

210630_s_at

211904_PM_x_at

211904_x_at

3439834

3439835

3439837

3439838

3439839

3439840

3439841

3439842

3439844

3439849

3439850

3439851

3439853

3439854

3439857

3439858

3439859

3439861

3439862

3439863

3439864

3439865

3439866

3439867

3439868

3439869

3439873

3439879

40744_at

5893

7960261

A_23_P64990

A_33_P3242703

GE58929

GO:0000724

GO:0000730

GO:0003677

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0006281

GO:0006302

GO:0006310

GO:0006312

GO:0006974

GO:0010792

GO:0032991

GO:0032993

GO:0034599

GO:0042802

GO:0043226

GO:0045002

GO:0065003

GO:2000819

HMNXSV003010972

HMNXSV003021651

HMNXSV003039293

ILMN_1781345

L33262_s_at

PH_hs_0022642

TC12001087.hg

U27516_s_at

g4506394_3p_at

g4581007_3p_a_at

g4581009_3p_a_at

Participates

as an input of

as a component of

RAD52 heptamer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm]

p-Y104-RAD52 [nucleoplasm]

Inferred To

rad52 [nucleoplasm] (Xenopus tropicalis)

RAD52 [nucleoplasm] (Bos taurus)

RAD52 [nucleoplasm] (Canis familiaris)

RAD52 [nucleoplasm] (Dictyostelium discoideum)

RAD52 [nucleoplasm] (Gallus gallus)

RAD52 [nucleoplasm] (Saccharomyces cerevisiae)

RAD52 [nucleoplasm] (Sus scrofa)

rti1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of RAD52 [nucleoplasm] (Xenopus tropicalis)

Rad52 [nucleoplasm] (Mus musculus)

Rad52 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001284349.1, XP_005253778.1, NP_001284348.1, NP_602296.2, XP_005253777.1, XP_011519292.1, XP_016875258.1, XP_011519293.1

OpenTargets

ENSG00000002016

HPA

ENSG00000002016-RAD52

GeneCards

P43351

Ensembl

ENST00000468231, ENSP00000436008, ENSP00000351284, ENSG00000002016, ENSP00000440268, ENST00000541619, ENSP00000443254, ENST00000461568, ENSP00000434703, ENST00000545564, ENST00000430095, ENST00000544742, ENSP00000438965, ENSP00000387901, ENST00000358495

PRO

P43351

Pharos - Targets

P43351

PDB

1H2I, 8H1P, 5XRZ, 5JRB, 5XS0, 1KN0

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43351 RAD52	3	monoSUMO1-K411,K412,K414-RAD52 [nucleoplasm] (R-HSA-4568909) RAD52 [nucleoplasm] (R-HSA-62639) p-Y104-RAD52 [nucleoplasm] (R-HSA-5686588)	0.82	7
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.675	9
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.635	3
UniProt:P35244 RPA3	1	RPA3 [nucleoplasm] (R-HSA-68459)	0.623	3
UniProt:Q13952-2 NFYC			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O15131 KPNA5	2	KPNA5 [nucleoplasm] (R-HSA-1176068) KPNA5 [cytosol] (R-HSA-1176062)	0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:Q8NG50 RDM1			0.556	5
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.556	5

Cite Us!