Reactome | NOD1 induced apoptosis is mediated by RIP2 and CARD8

NOD1 induced apoptosis is mediated by RIP2 and CARD8

Stable Identifier

R-HSA-622420

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NOD1 induced apoptosis is mediated by RIP2 and CARD8

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NOD1 was found to coimmunoprecipitate with several procaspases containing long prodomains with CARDs or DEDs, including caspase-1, caspase-2, caspase-4, caspase-8, and caspase-9, but not those with short prodomains like caspase-3 or caspase-7. Deletions of caspase-9 determined that the CARD domain was required for this interaction (Inohara et al. 1999). More recently, NOD1 activation of apoptosis was shown to require the RIP2-dependent activation of caspase-8, this effect being inhibited by CASP8 and FADD-like apoptosis regulator, also called FLICE-inhibitory protein, FLIP or CLARP (da Silva Correia et al. 2007), which is a specific inhibitor of caspase-8 (Irmler et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
10329646	Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB Ni, J, Carrio, R, Yee, C, Hu, Y, Nunez, G, Koseki, T, Merino, J, Chen, S, Inohara, N, del Peso, L, Liu, D	J Biol Chem	1999