Reactome | Postsynaptic nicotinic acetylcholine receptors

Postsynaptic nicotinic acetylcholine receptors

Stable Identifier

R-HSA-622327

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Postsynaptic nicotinic acetylcholine receptors

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Nicotinic acetylcholine receptors are found in the postsynaptic terminals and these receptors are responsible in mediating postsynaptic currents. Most common types of neuronal postsynaptic nicotinic acetylcholine receptors are homomeric alpha 7 containing acetylcholine receptors. The densities of acetylcholine receptors are found to be similar to NMDA and AMPA receptors at these sites. Nicotinic acetylcholine receptors may permit both sodium and calcium ions, however, the ratio of sodium and calcium influx makes the receptors either highly sodium permeable or highly calcium permeable.

Literature References

PubMed ID	Title	Journal	Year
17009926	Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system Bertrand, D, Dani, JA	Annu Rev Pharmacol Toxicol	2007
17689497	Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors Dani, JA, Placzek, AN, McKay, BE	Biochem Pharmacol	2007
12036180	Nicotinic acetylcholine receptors in autonomic ganglia Skok, VI	Auton Neurosci	2002