Reactome | AGPAT2 [endoplasmic reticulum membrane]

AGPAT2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-61805

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

1-acyl-sn-glycerol-3-phosphate acyltransferase beta , 1- AGP acyltransferase 2, Lysophosphatidic acid acyltransferase-beta, LPAAT-beta, 1-acylglycerol-3-phosphate O- acyltransferase 2

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
        
        AGPAT2 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15120 AGPAT2

Gene Names

AGPAT2

Chain

signal peptide:1-23, chain:24-278

Reference Genes

BioGPS Gene:10555 AGPAT2

COSMIC (genes):AGPAT2 AGPAT2

CTD Gene:10555 AGPAT2

dbSNP Gene:10555 AGPAT2

ENSEMBL:ENSG00000169692 AGPAT2

HGNC:325 AGPAT2

KEGG:hsa:10555 AGPAT2

Monarch:10555 AGPAT2

NCBI Gene:10555 AGPAT2

OMIM:603100 AGPAT2

UCSC:O15120 AGPAT2

Reference Transcript

Other Identifiers

10555

11720544_x_at

11745598_x_at

17100087

210678_3p_s_at

210678_PM_s_at

210678_s_at

3230283

3230284

3230285

3230286

3230287

3230288

3230289

3230290

3230291

3230292

3230293

3230310

3230311

32837_PM_at

32837_at

58770_f_at

58772_r_at

8165258

A_32_P26103

A_33_P3360540

GE62758

GO:0001819

GO:0001961

GO:0003824

GO:0003841

GO:0005783

GO:0005789

GO:0005886

GO:0006629

GO:0006644

GO:0006654

GO:0008544

GO:0008654

GO:0009410

GO:0016020

GO:0016024

GO:0016740

GO:0016746

GO:0019432

GO:0035579

GO:0043226

GO:0048856

HMNXSV003034788

ILMN_1681081

ILMN_1732176

ILMN_2377430

PH_hs_0012150

TC09001738.hg

U56418_at

g2155239_3p_a_at

g2155239_3p_s_at

Participates

as an output of

AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)

as a member of

AGPAT [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

AGPAT2 [plasma membrane]

AGPAT2 [specific granule membrane]

Inferred To

Agpat1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

SLC1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

agpat2 [endoplasmic reticulum membrane] (Danio rerio)

agpat2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Agpat2 [endoplasmic reticulum membrane] (Mus musculus)

Agpat2 [endoplasmic reticulum membrane] (Rattus norvegicus)

AGPAT2 [endoplasmic reticulum membrane] (Bos taurus)

AGPAT2 [endoplasmic reticulum membrane] (Canis familiaris)

AGPAT2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

AGPAT2 [endoplasmic reticulum membrane] (Gallus gallus)

AGPAT2 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

AGPAT2 [endoplasmic reticulum membrane] (Sus scrofa)

acl-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006403.2, NP_001012745.1

ENSEMBL

ENST00000371694, ENSP00000360759, ENST00000371696, ENSP00000360761

OpenTargets

ENSG00000169692

HPA

ENSG00000169692-AGPAT2

ZINC - Substances

PLCB_HUMAN

ZINC target

O15120

PRO

O15120

Pharos - Targets

O15120

Orphanet

AGPAT2

ZINC - Predictions - Purchasable

PLCB_HUMAN

HMDB Protein

HMDBP01579