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P2RX1 [plasma membrane]
Stable Identifier
R-HSA-61129
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2X purinoceptor 1, ATP receptor, P2X1, Purinergic receptor
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Binding of ATP to P2X receptors (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX1 [plasma membrane] (Homo sapiens)
P2X purinoreceptors:ATP [plasma membrane] (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX1 [plasma membrane] (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
P2X1-mediated entry of Ca++ from plasma (Homo sapiens)
P2X purinoreceptors:ATP [plasma membrane] (Homo sapiens)
P2RX receptors [plasma membrane] (Homo sapiens)
P2RX1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
P2RX1 [plasma membrane] (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
P2RX1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51575 P2RX1
Gene Names
P2RX1, P2X1
Chain
chain:1-399
Reference Genes
BioGPS Gene:5023 P2RX1
COSMIC (genes):P2RX1 P2RX1
CTD Gene:5023 P2RX1
dbSNP Gene:5023 P2RX1
ENSEMBL:ENSG00000108405 P2RX1
HGNC:8533 P2RX1
KEGG:hsa:5023 P2RX1
Monarch:5023 P2RX1
NCBI Gene:5023 P2RX1
OMIM:600845 P2RX1
UCSC:P51575 P2RX1
Reference Transcript
RefSeq:NM_002558.3 P2RX1
Other Identifiers
11730955_a_at
11730956_a_at
16839872
210401_PM_at
210401_at
33535_at
3741770
3741771
3741772
3741773
3741775
3741776
3741777
3741778
3741779
3741780
3741781
3741782
3741783
3741784
3741785
3741786
3741787
3741792
3741793
3741794
3741795
5023
8011499
A_23_P372848
GE59180
GO:0000166
GO:0001614
GO:0002554
GO:0003013
GO:0003056
GO:0004931
GO:0005215
GO:0005216
GO:0005261
GO:0005515
GO:0005524
GO:0005886
GO:0006629
GO:0006811
GO:0006915
GO:0006940
GO:0007165
GO:0007320
GO:0008217
GO:0009897
GO:0012501
GO:0015267
GO:0016020
GO:0019228
GO:0019229
GO:0019722
GO:0022414
GO:0023052
GO:0030168
GO:0030667
GO:0032991
GO:0033198
GO:0034220
GO:0035249
GO:0035579
GO:0035590
GO:0042802
GO:0043270
GO:0043924
GO:0044877
GO:0045121
GO:0045211
GO:0046513
GO:0048787
GO:0051649
GO:0051924
GO:0055085
GO:0060079
GO:0060089
GO:0070588
GO:0097159
GO:0098655
GO:0098978
GO:0099509
GO:0099604
GO:1905665
GO:2000300
HMNXSV003002851
ILMN_1758529
PH_hs_0003085
TC17001014.hg
U45448_s_at
g1314356_3p_at
Participates
as a member of
P2RX receptors [plasma membrane] (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
P2RX1 [specific granule membrane]
P2RX1 [secretory granule membrane]
Inferred To
p2xC [plasma membrane]
(Dictyostelium discoideum)
p2xB [plasma membrane]
(Dictyostelium discoideum)
P2RX1 [plasma membrane]
(Bos taurus)
P2RX1 [plasma membrane]
(Canis familiaris)
P2RX1 [plasma membrane]
(Danio rerio)
P2RX1 [plasma membrane]
(Gallus gallus)
P2RX1 [plasma membrane]
(Mus musculus)
P2RX1 [plasma membrane]
(Rattus norvegicus)
P2RX1 [plasma membrane]
(Sus scrofa)
P2RX1 [plasma membrane]
(Xenopus tropicalis)
p2xD [plasma membrane]
(Dictyostelium discoideum)
Homologues of P2RX1 [plasma membrane]
(Dictyostelium discoideum)
p2xA [plasma membrane]
(Dictyostelium discoideum)
p2xE [plasma membrane]
(Dictyostelium discoideum)
Cross References
ZINC - World Drugs
P2RX1_HUMAN
Guide to Pharmacology - Targets
478
ENSEMBL
ENSP00000225538
,
ENST00000225538
OpenTargets
ENSG00000108405
ZINC - Substances
P2RX1_HUMAN
ZINC - Biogenic
P2RX1_HUMAN
ZINC target
P51575
PRO
P51575
GlyGen
P51575
ZINC - Investigational
P2RX1_HUMAN
ZINC - Metabolites
P2RX1_HUMAN
HPA
ENSG00000108405-P2RX1
Pharos - Targets
P51575
ZINC - Predictions - Purchasable
P2RX1_HUMAN
HMDB Protein
HMDBP07859
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.527
2
UniProt:P37268 FDFT1
1
FDFT1 [endoplasmic reticulum membrane]
(R-HSA-191369)
0.527
3
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