Reactome | OPRM1 [plasma membrane]

OPRM1 [plasma membrane]

Stable Identifier

R-HSA-60951

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Mu-type opioid receptor, MOR-1

Locations in the PathwayBrowser for interactor UniProt:Q5T9L3 WLS

Expand all

External Reference Information

External Reference

UniProt:P35372 OPRM1

Gene Names

OPRM1, MOR1

Chain

chain:1-400

Reference Genes

BioGPS Gene:4988 OPRM1

COSMIC (genes):OPRM1 OPRM1

CTD Gene:4988 OPRM1

dbSNP Gene:4988 OPRM1

ENSEMBL:ENSG00000112038 OPRM1

ENSEMBL_homo_sapiens_GENE:ENSG00000112038.18 OPRM1

HGNC:8156 OPRM1

KEGG Gene (Homo sapiens):4988 OPRM1

Monarch:4988 OPRM1

NCBI Gene:4988 OPRM1

OMIM:600018 OPRM1

UCSC:P35372 OPRM1

Reference Transcript

Other Identifiers

11737630_a_at

11738151_a_at

11738393_a_at

11752997_x_at

207989_PM_at

207989_at

207994_PM_s_at

207994_s_at

211359_PM_s_at

211359_s_at

2932220

2932223

2932224

2932225

2932226

2932227

2932228

2932229

2932239

2932240

2932241

2932243

2932244

2932245

2932249

2932250

2932251

2932253

2932254

2932255

2932258

2932259

2932260

2932264

2932265

2932266

2932267

2932268

2932269

2932274

2932275

34534_at

34535_at

34536_g_at

4988

A_14_P105385

A_14_P106090

A_14_P118771

A_23_P145480

A_24_P397613

GE57687

GO:0001965

GO:0004930

GO:0004979

GO:0004985

GO:0005215

GO:0005245

GO:0005515

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007200

GO:0007204

GO:0007218

GO:0007600

GO:0008285

GO:0016020

GO:0019233

GO:0023052

GO:0030154

GO:0030424

GO:0030425

GO:0031410

GO:0031681

GO:0038003

GO:0038047

GO:0042923

GO:0042995

GO:0043005

GO:0043204

GO:0043226

GO:0043950

GO:0043951

GO:0045019

GO:0045202

GO:0045429

GO:0048149

GO:0048856

GO:0050769

GO:0050877

GO:0051481

GO:0055085

GO:0060089

GO:0061358

GO:0070374

GO:0070588

GO:0071315

GO:0080135

GO:2000310

HMNXSV003026707

HMNXSV003027968

HMNXSV003042053

ILMN_1689129

ILMN_1739357

ILMN_1803261

ILMN_1812641

ILMN_2275199

ILMN_2373155

L25119_at

PH_hs_0000317

g4505514_3p_at

g607911_3p_a_at

Participates

as a member of

as an output of

as an input of

Opioid binds MOR (Homo sapiens)

as a component of

Opioid:MOR [plasma membrane] (Homo sapiens)

Inferred To

npr-16 [plasma membrane] (Caenorhabditis elegans)

npr-26 [plasma membrane] (Caenorhabditis elegans)

AstC-R1 [plasma membrane] (Drosophila melanogaster)

oprm1 [plasma membrane] (Xenopus tropicalis)

AstC-R2 [plasma membrane] (Drosophila melanogaster)

OPRM1 [plasma membrane] (Bos taurus)

OPRM1 [plasma membrane] (Caenorhabditis elegans)

OPRM1 [plasma membrane] (Canis familiaris)

OPRM1 [plasma membrane] (Gallus gallus)

OPRM1 [plasma membrane] (Sus scrofa)

npr-23 [plasma membrane] (Caenorhabditis elegans)

Rh7 [plasma membrane] (Drosophila melanogaster)

Homologues of OPRM1 [plasma membrane] (Caenorhabditis elegans)

Homologues of OPRM1 [plasma membrane] (Drosophila melanogaster)

npr-24 [plasma membrane] (Caenorhabditis elegans)

npr-28 [plasma membrane] (Caenorhabditis elegans)

npr-18 [plasma membrane] (Caenorhabditis elegans)

Oprm1 [plasma membrane] (Mus musculus)

Oprm1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001138752.1, NP_001272453.1, NP_001138757.1, NP_001138753.1, NP_001272455.1, NP_001138751.1, NP_001138756.1, NP_001272456.1, XP_016866395.1, NP_001138755.1, NP_001008503.2, NP_001272457.1, NP_001272452.1, NP_001138754.1, NP_000905.3, NP_001008504.2, NP_001138758.1, NP_001138759.1, NP_001008505.2

ZINC - World Drugs

OPRM_HUMAN

Guide to Pharmacology - Targets

319

OpenTargets

ENSG00000112038

ZINC - FDA approved

OPRM_HUMAN

ZINC - Substances

OPRM_HUMAN

ZINC target

P35372

ZINC - Biogenic

OPRM_HUMAN

PRO

P35372

PDB

8EFO, 8F7R, 8F7Q, 8EFQ, 8EF5, 8EFL, 8EF6, 8EFB

ZINC - Investigational

OPRM_HUMAN

ZINC - Metabolites

OPRM_HUMAN

HPA

ENSG00000112038-OPRM1

GeneCards

P35372

Ensembl

ENST00000330432, ENSP00000430575, ENST00000435918, ENST00000419506, ENSP00000411903, ENSP00000403549, ENSP00000394624, ENSP00000410497, ENSP00000430876, ENST00000434900, ENST00000519083, ENSP00000430097, ENST00000524163, ENST00000520708, ENSP00000399359, ENST00000522236, ENST00000522555, ENST00000414028, ENST00000337049, ENSP00000428018, ENSP00000338381, ENST00000428397, ENST00000524150, ENST00000522739, ENSP00000229768, ENSP00000328264, ENSP00000413752, ENST00000229768, ENSP00000429719, ENSG00000112038, ENST00000518759, ENSP00000430260, ENST00000452687, ENSP00000431048, ENSP00000429373

Pharos - Targets

P35372

ZINC - Predictions - Purchasable

OPRM_HUMAN

HMDB Protein

HMDBP02643

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5T9L3 WLS	5	WLS [extracellular exosome] (R-HSA-3781960) WLS [endocytic vesicle membrane] (R-HSA-3781954) WLS [early endosome membrane] (R-HSA-3247745) WLS [Golgi membrane] (R-HSA-3247747) WLS [plasma membrane] (R-HSA-3247746)	0.819	11
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.69	5
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.675	4
UniProt:P35212 GJA4	1	GJA4 [endoplasmic reticulum membrane] (R-HSA-190657)	0.635	3
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.602	5
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.581	4
UniProt:Q9Y679 AUP1			0.581	4
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.581	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.581	4
UniProt:Q15942 ZYX			0.508	2
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.508	2
UniProt:O43255 SIAH2	1	SIAH2 [cytosol] (R-HSA-374566)	0.508	3
UniProt:Q9H3M0 KCNF1	1	KCNF1 [plasma membrane] (R-HSA-977450)	0.488	2

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