Reactome | Mis18 complex binds the centromere

Mis18 complex binds the centromere

Stable Identifier

R-HSA-606349

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The Mis18 complex (containing Mis18-alpha, Mis18-beta, Mis18BP1, RBap46, and RbAp48) transiently binds the centromere in late anaphase-telophase to early G1. The mechanism by which the Mis18 complex binds the centromere is unknown. The Mis18 complex is required for deposition of new CENPA-containing nucleosomes at the centromere. The CENPH-I complex is constitutively associated with centromeres and is required for deposition of new CENPA-containing nucleosomes.

Literature References

PubMed ID	Title	Journal	Year
16622420	The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres Okada, M, McLeod, IX, Hori, T, Yates, JR 3rd, Cheeseman, IM, Okawa, K, Fukagawa, T, Desai, A	Nat Cell Biol	2006
15369671	Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres Yanagida, M, Adachi, Y, Fujita, Y, Hayashi, T, Takahashi, K, Iwasaki, O	Cell	2004
17339379	Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin Monen, J, Oegema, K, Maddox, PS, Desai, A, Hyndman, F	J Cell Biol	2007
17199038	Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1 Hayashi, T, Kiyomitsu, T, Yanagida, M, Obuse, C, Kokubu, A, Fujita, Y, Toyoda, Y	Dev Cell	2007