Mis18 complex binds the centromere

Stable Identifier
Reaction [binding]
Homo sapiens
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The Mis18 complex (containing Mis18-alpha, Mis18-beta, Mis18BP1, RBap46, and RbAp48) transiently binds the centromere in late anaphase-telophase to early G1. The mechanism by which the Mis18 complex binds the centromere is unknown. The Mis18 complex is required for deposition of new CENPA-containing nucleosomes at the centromere. The CENPH-I complex is constitutively associated with centromeres and is required for deposition of new CENPA-containing nucleosomes.
Literature References
PubMed ID Title Journal Year
16622420 The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

Okada, M, McLeod, IX, Hori, T, Yates, JR 3rd, Cheeseman, IM, Okawa, K, Fukagawa, T, Desai, A

Nat Cell Biol 2006
15369671 Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres

Yanagida, M, Adachi, Y, Fujita, Y, Hayashi, T, Takahashi, K, Iwasaki, O

Cell 2004
17339379 Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin

Monen, J, Oegema, K, Maddox, PS, Desai, A, Hyndman, F

J Cell Biol 2007
17199038 Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1

Hayashi, T, Kiyomitsu, T, Yanagida, M, Obuse, C, Kokubu, A, Fujita, Y, Toyoda, Y

Dev Cell 2007
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