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CASC5 [nucleoplasm]
Stable Identifier
R-HSA-606296
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hKNL1/CASC5, Protein CASC5, CASC5_HUMAN, KNL1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Nucleosome assembly (Homo sapiens)
Deposition of new CENPA-containing nucleosomes at the centromere (Homo sapiens)
HJURP:CENPA complex localizes to the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
Mis18 complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
RSF complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CASC5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NG31 KNL1
Gene Names
KNL1, CASC5, KIAA1570
Chain
chain:1-2342
Reference Genes
BioGPS Gene:57082 KNL1
COSMIC (genes):KNL1 KNL1
CTD Gene:57082 KNL1
dbSNP Gene:57082 KNL1
ENSEMBL:ENSG00000137812 KNL1
HGNC:24054 KNL1
KEGG:hsa:57082 KNL1
Monarch:57082 KNL1
NCBI Gene:57082 KNL1
OMIM:609173 KNL1
UCSC:Q8NG31 KNL1
Reference Transcript
RefSeq:NM_170589.4 KNL1
RefSeq:NM_144508.4 KNL1
Participates
as a component of
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CASC5 [cytosol]
Inferred To
Knl1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of CASC5 [nucleoplasm]
(Gallus gallus)
Ghost homologue of CASC5 [nucleoplasm]
(Mus musculus)
Ghost homologue of CASC5 [nucleoplasm]
(Sus scrofa)
KNL1 [nucleoplasm]
(Bos taurus)
KNL1 [nucleoplasm]
(Canis familiaris)
knl1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_733468.3
,
NP_653091.3
ENSEMBL
ENST00000399668
,
ENSG00000137812
,
ENST00000346991
,
ENSP00000335463
,
ENSP00000382576
OpenTargets
ENSG00000137812
GeneCards
KNL1
HPA
ENSG00000137812-KNL1
PRO
Q8NG31
Pharos - Targets
Q8NG31
GlyGen
Q8NG31
Orphanet
KNL1
PDB
8PPR
,
8Q5H
,
4A1G
,
4NF9
,
3SI5
,
6CZO
,
4NFA
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.693
3
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.59
4
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.527
2
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