New CENPA-containing nucleosomes are deposited at the centromere

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Reaction [omitted]
Homo sapiens
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A new centromeric nucleosome containing histone H2A, histone H2B, histone H4, and CENPA is deposited at the centromere in late telophase/early G1 phase. The exact mechanism by which the new CENPA-containing nucleosome is transferred to DNA is unknown. HJURP directly binds newly synthesized CENPA before deposition. The Mis18 and HJURP complexes are required for deposition of newly synthesized CENPA-containing nucleosomes. The exact stoichiometries and interactions of the complexes are unknown.

Literature References
PubMed ID Title Journal Year
16622420 The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

Okada, M, McLeod, IX, Hori, T, Yates, JR 3rd, Cheeseman, IM, Okawa, K, Fukagawa, T, Desai, A

Nat Cell Biol 2006
19410545 HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres

Daigo, Y, Lacoste, N, Dunleavy, EM, Tagami, H, Almouzni-Pettinotti, G, Nakatani, Y, Roche, D, Nakamura, Y, Ray-Gallet, D

Cell 2009
20566683 Dual recognition of CENP-A nucleosomes is required for centromere assembly

Straight, AF, Milks, KJ, Carroll, CW

J. Cell Biol. 2010
20080577 HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

Ouararhni, K, Hamiche, A, Dimitrov, S, Shuaib, M

Proc Natl Acad Sci U S A 2010
21768289 HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

Bassett, EA, Ward, JA, Stellfox, ME, Kuich, PH, Barnhart, MC, Foltz, DR, Black, BE

J. Cell Biol. 2011
19398759 Active establishment of centromeric CENP-A chromatin by RSF complex

Perpelescu, M, Yoda, K, Yang, H, Obuse, C, Nozaki, N

J Cell Biol 2009
19410544 Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP

Wood, S, Jansen, LE, Yates, JR 3rd, Foltz, DR, Black, BE, Bailey, AO, Cleveland, DW, Bassett, EA

Cell 2009
17199038 Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1

Hayashi, T, Kiyomitsu, T, Yanagida, M, Obuse, C, Kokubu, A, Fujita, Y, Toyoda, Y

Dev Cell 2007
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