New CENPA-containing nucleosomes are deposited at the centromere

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Reaction [omitted]
Homo sapiens
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A new centromeric nucleosome containing histone H2A, histone H2B, histone H4, and CENPA is deposited at the centromere in late telophase/early G1 phase. The exact mechanism by which the new CENPA-containing nucleosome is transferred to DNA is unknown. HJURP directly binds newly synthesized CENPA before deposition. The Mis18 and HJURP complexes are required for deposition of newly synthesized CENPA-containing nucleosomes. The exact stoichiometries and interactions of the complexes are unknown.

Literature References
PubMed ID Title Journal Year
19410545 HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres

Dunleavy, EM, Roche, D, Tagami, H, Lacoste, N, Ray-Gallet, D, Nakamura, Y, Daigo, Y, Nakatani, Y, Almouzni-Pettinotti, G

Cell 2009
16622420 The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

Okada, M, Cheeseman, IM, Hori, T, Okawa, K, McLeod, IX, Yates, JR 3rd, Desai, A, Fukagawa, T

Nat Cell Biol 2006
20566683 Dual recognition of CENP-A nucleosomes is required for centromere assembly

Carroll, CW, Milks, KJ, Straight, AF

J. Cell Biol. 2010
20080577 HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

Shuaib, M, Ouararhni, K, Dimitrov, S, Hamiche, A

Proc Natl Acad Sci U S A 2010
21768289 HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

Barnhart, MC, Kuich, PH, Stellfox, ME, Ward, JA, Bassett, EA, Black, BE, Foltz, DR

J. Cell Biol. 2011
19398759 Active establishment of centromeric CENP-A chromatin by RSF complex

Perpelescu, M, Nozaki, N, Obuse, C, Yang, H, Yoda, K

J Cell Biol 2009
19410544 Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP

Foltz, DR, Jansen, LE, Bailey, AO, Yates, JR 3rd, Bassett, EA, Wood, S, Black, BE, Cleveland, DW

Cell 2009
17199038 Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1

Fujita, Y, Hayashi, T, Kiyomitsu, T, Toyoda, Y, Kokubu, A, Obuse, C, Yanagida, M

Dev Cell 2007
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