Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MT-ND3 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60557
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase chain 3 (EC 1.6.5.3)
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Homo sapiens)
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P03897 MT-ND3
Gene Names
MT-ND3, MTND3, NADH3, ND3
Chain
chain:1-115
Reference Genes
BioGPS Gene:4537 MT-ND3
COSMIC (genes):MT-ND3 MT-ND3
CTD Gene:4537 MT-ND3
dbSNP Gene:4537 MT-ND3
ENSEMBL:ENSG00000198840 MT-ND3
HGNC:7458 MT-ND3
KEGG:hsa:4537 MT-ND3
Monarch:4537 MT-ND3
NCBI Gene:4537 MT-ND3
OMIM:516002 MT-ND3
UCSC:P03897 MT-ND3
Reference Transcript
RefSeq:NC_012920.1 MT-CYB
Other Identifiers
1553588_PM_at
1553588_at
17100667
17100669
17100671
17100673
17126270
4037648
4037649
4037651
4037653
4037655
4037657
4037658
4037659
4037660
4537
8165672
8165674
8165676
A_23_P315252
A_23_P360209
A_33_P3336696
GO:0003824
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0006091
GO:0006120
GO:0006979
GO:0008137
GO:0009060
GO:0009642
GO:0009725
GO:0016020
GO:0016491
GO:0042776
GO:0043226
GO:0045271
GO:0055085
GO:0055086
GO:0071385
GO:1901135
GO:1902600
HMNXSV003008622
HMNXSV003015713
Hs2Affx.1.52.S1_3p_at
TC0M000006.hg
TC0M000007.hg
Participates
as a component of
TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mt-nd3 [mitochondrial inner membrane]
(Danio rerio)
mt-nd3 [mitochondrial inner membrane]
(Xenopus tropicalis)
nduo-3 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Ghost homologue of MT-ND3 [mitochondrial inner membrane]
(Canis familiaris)
Mt-nd3 [mitochondrial inner membrane]
(Rattus norvegicus)
mt-Nd3 [mitochondrial inner membrane]
(Mus musculus)
mt:ND3 [mitochondrial inner membrane]
(Drosophila melanogaster)
MT-ND3 [mitochondrial inner membrane]
(Bos taurus)
MT-ND3 [mitochondrial inner membrane]
(Gallus gallus)
MT-ND3 [mitochondrial inner membrane]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000355206
,
ENSG00000198840
,
ENST00000361227
OpenTargets
ENSG00000198840
IntEnz
7.1.1.2
GeneCards
MT-ND3
HPA
ENSG00000198840-MT-ND3
PRO
P03897
Pharos - Targets
P03897
GlyGen
P03897
Orphanet
MT-ND3
HMDB Protein
HMDBP00182
PDB
5XTD
,
5XTC
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text