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NME2 [cytosol]
Stable Identifier
R-HSA-60024
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
non-metastatic cells 2, protein (NM23B) expressed in, Nucleoside diphosphate kinase B, nm23-H2, Nucleoside diphosphate kinase B , NDK B, NDP kinase B, C-myc purine-binding transcription factor PUF
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Homo sapiens)
NME1,2 hexamers [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase B hexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Homo sapiens)
NME1,2 hexamers [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
nucleoside diphosphate kinase B hexamer [cytosol] (Homo sapiens)
NME2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22392 NME2
Gene Names
NME2, NM23B
Chain
chain:1-152
Reference Genes
BioGPS Gene:4831 NME2
BioGPS Gene:654364 NME2
COSMIC (genes):NME2 NME2
CTD Gene:4831 NME2
CTD Gene:654364 NME2
dbSNP Gene:4831 NME2
dbSNP Gene:654364 NME2
ENSEMBL:ENSG00000243678 NME2
HGNC:7850 NME2
KEGG Gene (Homo sapiens):4831 NME2
KEGG Gene (Homo sapiens):654364 NME2
Monarch:4831 NME2
Monarch:654364 NME2
NCBI Gene:4831 NME2
NCBI Gene:654364 NME2
OMIM:156491 NME2
UCSC:P22392 NME2
Reference Transcript
RefSeq:NM_001018136.2 NME2
RefSeq:NM_001018138.1 NME2
RefSeq:NM_002512.3 NME2
RefSeq:NM_001018139.2 NME2
RefSeq:NM_001018137.2 NME2
Other Identifiers
0003850114
11718294_s_at
1980_s_at
201268_PM_at
201268_at
33415_at
3434301
3434305
3434307
3726961
3726962
3726964
3726965
3726966
3726967
3726968
3726969
3726971
3726974
3726975
4831
8180386
8180387
8180388
8180389
A_23_P141405
GE61684
GO:0000166
GO:0001726
GO:0003674
GO:0003677
GO:0003713
GO:0004550
GO:0004673
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006165
GO:0006183
GO:0006228
GO:0006241
GO:0006464
GO:0007155
GO:0007165
GO:0007229
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009117
GO:0009142
GO:0016301
GO:0016310
GO:0016740
GO:0018106
GO:0019003
GO:0030027
GO:0030154
GO:0031410
GO:0034641
GO:0034774
GO:0042981
GO:0042995
GO:0043066
GO:0043167
GO:0043226
GO:0044281
GO:0045618
GO:0045682
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0050679
GO:0051880
GO:0055086
GO:0070062
GO:0071944
GO:1904813
HMNXSV003052386
ILMN_1657884
ILMN_1662905
ILMN_1673781
ILMN_1694012
ILMN_1708184
ILMN_2234873
ILMN_2414007
TC17002881.hg
g4505408_3p_s_at
Participates
as a component of
nucleoside diphosphate kinase 4A:2B heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 1A:5B heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 5A:1B heterohexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase B hexamer [cytosol] (Homo sapiens)
nucleoside diphosphate kinase 2A:4B heterohexamer [cytosol] (Homo sapiens)
NME1:NME2 hexamer [cytosol] (Homo sapiens)
Other forms of this molecule
NME2 [secretory granule lumen]
NME2 [extracellular region]
NME2 [ficolin-1-rich granule lumen]
Inferred To
NME2 [cytosol]
(Bos taurus)
NME2 [cytosol]
(Canis familiaris)
NME2 [cytosol]
(Gallus gallus)
NME2 [cytosol]
(Sus scrofa)
YNK1 [cytosol]
(Saccharomyces cerevisiae)
nme2b.1 [cytosol]
(Danio rerio)
NME1 [cytosol]
(Plasmodium falciparum)
ndkC-1 [cytosol]
(Dictyostelium discoideum)
nme2 [cytosol]
(Xenopus tropicalis)
ndk-1 [cytosol]
(Caenorhabditis elegans)
ndk1 [cytosol]
(Schizosaccharomyces pombe)
awd [cytosol]
(Drosophila melanogaster)
Nme2 [cytosol]
(Mus musculus)
Nme2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_002503.1
,
NP_001018146.1
,
NP_001018148.1
,
NP_001018147.1
,
NP_001018149.1
ZINC - World Drugs
NDKB_HUMAN
OpenTargets
ENSG00000243678
IntEnz
2.7.4.6
,
2.7.13.3
HPA
ENSG00000243678-NME2
GeneCards
P22392
Ensembl
ENSP00000426976
,
ENST00000512737
,
ENST00000513177
,
ENSP00000376886
,
ENSP00000421064
,
ENSP00000426901
,
ENST00000514264
,
ENST00000393190
,
ENST00000503064
,
ENSG00000243678
,
ENSP00000425581
ZINC target
P22392
PRO
P22392
Pharos - Targets
P22392
HMDB Protein
HMDBP00112
PDB
1NUE
,
1NSK
,
3BBC
,
3BBF
,
3BBB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.525
2
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